Cancer Cell Dormancy

Clinical Tumor Dormancy.- In vitro and in vivo systems to study tumor dormancy and the transition to overt metastases induced by the fibrotic milieu.- Modeling tumor cell dormancy in an ex vivo liver metastatic niche.- Bone marrow stoma co-cultivation model of breast cancer dormancy.- Establishing and characterizing chemotherapy-induced immunological dormant tumor cell lines.- In ovo xenograft model to study tumor dormancy, tumor cell dissemination and metastasis.- Pre-clinical mouse intraductal model (MIND) to study metastatic dormancy in estrogen receptor-positive breast cancer.- Intracardiac injection mouse model to study cancer cell dormancy in brain metastasis.- Modeling the depth of cellular dormancy from RNA-sequencing data.- Crispr knock-ins in organoids to track tumor cell subpopulations.- A live tracker of dormant disseminated tumor cells.- Characterizing rare dormant and cycling lineages using thewatermelon system.- Kiss1 and kisspeptins detection in cell lines.- Detection of ROS in dormant breast cancer cell.-13C tracer analysis and metabolomics in dormant cancer cells.- Visualizing the cell-matrix interactions and cytoskeleton of disseminated tumor cells.