Leukaemia Diagnosis (eBook)
656 Seiten
Wiley (Verlag)
978-1-394-21860-8 (ISBN)
Authoritative reference on classifying and diagnosing leukaemia, with practical guidance on using various laboratory techniques included
Leukaemia Diagnosis is a practical reference on the principles of leukaemia diagnosis and classification that illustrates and explains in a user-friendly way how different laboratory techniques are used to achieve an accurate interpretation. To aid in reader comprehension, over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma are included, supplemented by histological, cytogenetic and immunophenotyping images.
This newly revised and updated Sixth Edition includes recent developments, highlights the growing importance of molecular genetics, and incorporates the recent 5th edition of the WHO guidelines and the International Consensus Classification for leukaemia diagnosis and classification throughout the text. Information on cytogenetic and molecular genetic abnormalities in leukaemia is also included, along with characteristic immunophenotypic characteristics of different categories of leukaemia.
Written by world-renowned authors in the field, Barbara Bain and Mike Leach, Leukaemia Diagnosis covers sample topics such as:
- The nature of leukaemia, cytology, cytochemistry, and the morphological classification of acute leukaemia, with an index of commonly used abbreviations
- Immunophenotyping and cytogenetic/molecular genetic analysis, and integration of morphological, immunophenotypic and genetic information with the WHO classifications
- Acute lymphoblastic leukaemia, acute leukaemia of ambiguous lineage, and the myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
- Chronic myeloid leukaemias, lymphoid leukaemias of mature B, T, and natural killer cells, and leukaemia diagnosis in resource-poor countries
The Sixth Edition of Leukaemia Diagnosis is a highly valuable resource for trainee haematologists and laboratory scientists in haematology and related disciplines. The text also serves as a useful reference and teaching aid for those who already have expertise in this field.
Barbara J. Bain is an Australian haematologist. She is Professor of Diagnostic Haematology at the Imperial College London Faculty of Medicine and a consultant at St Mary's Hospital, London. She is known as the author of reference textbooks in the field of haematology that form the core curriculum for laboratory morphology and pathology. She recently received an AM in the 2020 Queen's Birthday Honours and in 2018 a European Haematology Association Mentoring and Teaching Award.
Mike Leach is a haematologist with an interest in diagnostic haematopathology. He is a Consultant at the Beatson West of Scotland Cancer Centre and Gartnavel Laboratory in Glasgow, UK. He is known for a series of textbooks in this field with a focus on haematology diagnosis and the application of flow cytometry.
Leukaemia Diagnosis Authoritative reference on classifying and diagnosing leukaemia, with practical guidance on using various laboratory techniques included Leukaemia Diagnosis is a practical reference on the principles of leukaemia diagnosis and classification that illustrates and explains in a user-friendly way how different laboratory techniques are used to achieve an accurate interpretation. To aid in reader comprehension, over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma are included, supplemented by histological, cytogenetic and immunophenotyping images. This newly revised and updated Sixth Edition includes recent developments, highlights the growing importance of molecular genetics, and incorporates the recent 5th edition of the WHO guidelines and the International Consensus Classification for leukaemia diagnosis and classification throughout the text. Information on cytogenetic and molecular genetic abnormalities in leukaemia is also included, along with characteristic immunophenotypic characteristics of different categories of leukaemia. Written by world-renowned authors in the field, Barbara Bain and Mike Leach, Leukaemia Diagnosis covers sample topics such as: The nature of leukaemia, cytology, cytochemistry, and the morphological classification of acute leukaemia, with an index of commonly used abbreviations Immunophenotyping and cytogenetic/molecular genetic analysis, and integration of morphological, immunophenotypic and genetic information with the WHO classifications Acute lymphoblastic leukaemia, acute leukaemia of ambiguous lineage, and the myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms Chronic myeloid leukaemias, lymphoid leukaemias of mature B, T, and natural killer cells, and leukaemia diagnosis in resource-poor countries The Sixth Edition of Leukaemia Diagnosis is a highly valuable resource for trainee haematologists and laboratory scientists in haematology and related disciplines. The text also serves as a useful reference and teaching aid for those who already have expertise in this field.
Commonly Used Abbreviations
Specific cytogenetic abbreviations are shown in Table 2.10.
- aCML
- atypical chronic myeloid leukaemia
- AIDS
- acquired immune deficiency syndrome
- AIHA
- autoimmune haemolytic anaemia
- ALAL
- acute leukaemia of ambiguous lineage
- ALIP
- abnormal localisation of immature precursors
- ALL
- acute lymphoblastic leukaemia
- AML
- acute myeloid leukaemia
- AML‐MR
- myelodysplasia‐related AML
- AML‐MRC
- AML with myelodysplasia‐related changes
- ANAE
- α‐naphthyl acetate esterase
- ANBE
- α‐naphthyl butyrate esterase
- APAAP
- alkaline phosphatase–anti‐alkaline phosphatase (technique)
- APC
- allophycocyanin (a fluorochrome)
- APL
- acute promyelocytic leukaemia
- ATLL
- adult T‐cell leukaemia/lymphoma
- ATRA
- all‐trans‐retinoic acid
- AUL
- acute undifferentiated leukaemia
- B‐ALL
- B‐lineage acute lymphoblastic leukaemia
- B‐ALL/LBL
- B lymphoblastic leukaemia/lymphoma
- BCSH
- British Committee for Standards in Haematology
- BFU‐E
- burst‐forming unit – erythroid
- BM
- bone marrow
- c
- cytoplasmic or, in cytogenetic terminology, constitutional
- CAE
- naphthol AS‐D chloroacetate esterase, chloroacetate esterase (cytochemical stain)
- CAR
- chimaeric antigen receptor
- CBF
- core binding factor
- CCMUS
- clonal monocytosis of undetermined significance with cytopenia
- CCUS
- clonal cytopenia of undetermined significance
- CD
- cluster of differentiation
- CEL
- chronic eosinophilic leukaemia
- CFU‐E
- colony‐forming unit – erythroid
- CFU‐GM
- colony‐forming unit – granulocyte, macrophage
- CFU‐Meg
- colony‐forming unit – megakaryocyte
- CGH
- comparative genomic hybridisation
- CHIP
- clonal haematopoiesis of indeterminate potential
- cIg
- cytoplasmic immunoglobulin
- CLL
- chronic lymphocytic leukaemia
- CLL/PL
- chronic lymphocytic leukaemia, mixed cell type with prolymphocytoid cells
- CML
- chronic myeloid leukaemia
- CMML
- chronic myelomonocytic leukaemia
- CMUS
- clonal monocytosis of undetermined significance
- CNL
- chronic neutrophilic leukaemia
- CNS
- central nervous system
- CT
- computed tomography
- DIC
- disseminated intravascular coagulation
- DLBCL
- diffuse large B‐cell lymphoma
- DNA
- deoxyribonucleic acid
- EBER
- EBV early RNA
- EBV
- Epstein–Barr virus
- ECOG
- Eastern Cooperative Oncology Group
- EDTA
- ethylenediamine tetra‐acetic acid
- EGIL
- European Group for the Immunological Characterization of Leukemias
- EMA
- epithelial membrane antigen
- ERFC
- E‐rosette‐forming cells
- ETP‐ALL
- early T precursor lymphoblastic leukaemia/lymphoma
- FAB
- French–American–British
- FDG‐PET
- 18F‐fluorodeoxyglucose positron emission tomography
- FISH
- fluorescence in situ hybridisation
- FITC
- fluorescein isothiocyanate (a fluorochrome)
- FLIPI
- Follicular Lymphoma International Prognostic Index
- FSC
- forward scatter of light (flow cytometry term)
- G‐CSF
- granulocyte colony‐stimulating factor
- GM‐CSF
- granulocyte–macrophage colony‐stimulating factor
- G6PD
- glucose‐6‐phosphate dehydrogenase
- H&E
- haematoxylin and eosin (stain)
- Hb
- haemoglobin concentration
- HCL
- hairy cell leukaemia
- HES
- hypereosinophilic syndrome
- HIV
- human immunodeficiency virus
- HLA‐DR
- human leucocyte antigen DR
- HTLV‐1
- human T‐cell lymphotropic virus 1
- ICC
- International Consensus Classification
- ICUS
- idiopathic cytopenia of undetermined significance
- IDUS
- idiopathic dysplasia of uncertain significance
- Ig
- immunoglobulin
- IGH
- immunoglobulin heavy chain locus
- IGHV
- immunoglobulin heavy chain variable region genes
- IL
- interleukin
- IPSS
- International Prognostic Scoring System
- IPSS‐R
- International Prognostic Scoring System, Revised
- ITD
- internal tandem duplication
- IWGM‐MDS
- International Working Group on Morphology of MDS
- JMML
- juvenile myelomonocytic leukaemia
- KIR
- killer inhibitory receptor
- L1–L3
- categories of acute lymphoblastic leukaemia in the FAB classification
- LDH
- lactate dehydrogenase
- LEF1
- lymphoid enhancer‐binding factor 1
- LGL
- large granular lymphocyte/s
- M : E
- myeloid : erythroid
- M0–M7
- categories of acute myeloid leukaemia in the FAB classification
- m‐BCR
- minor breakpoint cluster region
- M‐BCR
- major breakpoint cluster region
- M‐FISH
- multiplex fluorescence in situ hybridisation
- MAC
- morphology–antibody–chromosomes (technique)
- MALT
- mucosa‐associated lymphoid tissue
- McAb
- monoclonal antibody/ies
- MCV
- mean cell volume
- MDS
- myelodysplastic neoplasm/syndrome/s
- MDS‐LB
- MDS with low blasts
- MDS‐LB‐MLD
- MDS‐LB and multilineage dysplasia
- MDS‐LB‐SLD
- MDS‐LB and single lineage dysplasia
- MDS/MPN
- myelodysplastic/myeloproliferative neoplasm/s
- MDS/MPN‐N
- MDS/MPN with neutrophilia
- MDS‐U
- myelodysplastic syndrome, unclassifiable
- MGG
- May–Grünwald–Giemsa (stain)
- MIC
- Morphology, Immunophenotype, Cytogenetics
- MIC‐M
- Morphology, Immunophenotype, Cytogenetics, Molecular genetics
- MLD
- multilineage dysplasia
- MN‐pCT
- myeloid neoplasm post cytotoxic therapy
- MPAL
- mixed phenotype acute leukaemia
- MPN
- myeloproliferative neoplasm/s
- MPO
- myeloperoxidase
- MRC
- Medical Research Council
- MRD
- measureable residual disease (previously minimal residual disease)
- MRI
- magnetic resonance imaging
- mRNA
- messenger RNA
- NAP
- neutrophil alkaline phosphatase
- NASA
- naphthol AS acetate esterase (cytochemical stain)
- NASDA
- naphthol AS‐D acetate esterase (cytochemical stain)
- NGS
- next generation sequencing
- NHL
- non‐Hodgkin lymphoma/s
- NK
- natural killer
- NOS
- not otherwise specified
- NRBC
- nucleated red blood cells
- NSE
- non‐specific esterase (cytochemical stain)
- PAS
- periodic acid–Schiff (cytochemical stain)
- PB
- peripheral blood
- PcAb
- polyclonal antibody/ies
- PCR
- polymerase chain reaction
- PE
- phycoerythrin (a fluorochrome)
- PerCP
- peridinin–chlorophyll protein complex (a fluorochrome)
- Ph
- Philadelphia (chromosome)
- PLL
- prolymphocytic leukaemia
- PMF
- primary myelofibrosis
- PPO
- platelet peroxidase
- PTD
- partial tandem duplication
- PV
- polycythaemia vera
- RA
- refractory anaemia
- RAEB
- refractory anaemia with excess of blasts
- RAEB‐T
- refractory anaemia with excess of blasts in transformation
- RARS
- refractory anaemia with ring sideroblasts
- RCMD
- refractory cytopenia with multilineage dysplasia
- RCUD
- refractory cytopenia with unilineage dysplasia
- RNA
- ribonucleic acid
- RQ‐PCR
- real‐time quantitative polymerase chain reaction
- RS
- ring sideroblasts
- RT‐PCR
- reverse transcriptase polymerase chain reaction
- SARS‐CoV‐2
- severe adult respiratory syndrome coronavirus 2
- SBB
- Sudan black B
- SKY
- spectral karyotyping
- SLD
- single lineage dysplasia
- SLVL
- splenic lymphoma with villous lymphocytes
- SmIg
- surface membrane immunoglobulin
- SMZL
- splenic marginal zone lymphoma
- SNP
- single nucleotide polymorphism
- SSC
- side scatter of light (flow cytometry term)
- T‐ALL/LBL
- T lymphoblastic leukaemia/lymphoma
- t‐AML
- therapy‐related acute myeloid leukaemia
- t‐MDS
- therapy‐related myelodysplastic syndrome
- TAM
- transient abnormal myelopoiesis
- TCR
- T‐cell receptor
- TdT
- terminal deoxynucleotidyl...
| Erscheint lt. Verlag | 6.2.2024 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin |
| Schlagworte | Hämatologie • Hämatologisches Labor • Hematology • laboratory hematology • Medical Science • Medizin |
| ISBN-10 | 1-394-21860-5 / 1394218605 |
| ISBN-13 | 978-1-394-21860-8 / 9781394218608 |
| Haben Sie eine Frage zum Produkt? |
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