Recombinant FSH (Puregon)

Preclinical Aspects-Comparative in vitro and in vivo studies on the biological characteristics of recFSHoEffects of recFSH on cultured human granulosa cellso Circulating bioactive and immunoreactive recFSH after administration to gonadotropin-deficient subjectsoFolliculogenesis in hypophysectomized rats after treatment with recFSHoRecFSH induces follicle growth and ovulation in the adult cyclic rat. Clinical Aspects-First established pregnancy and birth after ovarian stimulation with recFSHoRecFSH induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiencyoSingle-dose pharmacokinetics and pharmacodynamics of recFSH in gonadotropin-deficient volunteersoClinical outcome of pilot efficacy study on recFSH combined with various gonadotropin-releasing hormone agonist regimensoRecFSH and ovarian response in gonadotropin-deficient womenoFirst established pregnancy and birth after induction o f ovulation with recFSH in polycystic ovary syndromeoRecFSH an human chorionic gonadotropin for induction of spermatogenesis in hypogonadotropic malesoA prospective, randomized, assessor-blind, multicenter study comparing recombinant and urinary FSH in in vitro fertilization. Index.