Purging in Bone Marrow Transplantation

Discusses the rationale for the use of haematopoietic stem cell transplantation after high dose cytotoxic therapy. Gulatis describes methods for ex-vivo elimination (purging) of stem cells with emphasis on preclinical investigations and how to evaluate the clinical benefit.

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This book discusses the rationale for the use of haematopoietic stem cell transplantation after high dose cytotoxic therapy. Gulatis describes methods for ex-vivo elimination (purging) of stem cells, with emphasis on preclinical investigations and how to evaluate the clinical benefit. He also presents methods for eliminating T-cells in patients undergoing allogeneic BMT. Information related to complication of purging haematopoietic stem cell transplantations and unresolved issues that need further study are discussed.