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Pulmonary Surfactant

From Molecular Biology to Clinical Practice
Buch | Hardcover
766 Seiten
1992
Elsevier Science Ltd (Verlag)
978-0-444-89475-5 (ISBN)
219,95 inkl. MwSt
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There has been a spectacular development in both basic research on the pulmonary surfactant system and the clinical use of surfactant for treatment of lung diseases, especially in the neonatal period. In particular, the molecular biology and physiological roles of the surfactant-associated proteins (SP-A) have been clarified during the last few years; the structure and functions of these proteins therefore constitute an important hot topic, and are reviewed in several chapters of this volume. In the first half of the book, the emphasis remains on basic science, including surface chemistry and ultrastructure of surfactant components, the role of surfactant in lung mechanics and alveolar liquid homeostasis, and surfactant metabolism and its hormonal control. However, as mentioned above, clinical applications of surfactant research have become increasingly important and are therefore dealt with extensively in the remaining chapters. The publication also contains selected examples of new concepts emerging during the last few years to illustrate the fascinating complexity of the surfactant system.
Hence, the main mission of this volume is to catalyze the future development in this field with the exchange of ideas between scientific workers from different disciplines.

List of contributors. Preface. 1. History of surfactant research (M. Obladen). 2. Lipid components of the surfactant system (T. Akino). 3. The hydrophilic surfactant protein SP-A: molecular biology, structure and function (S. Hawgood). 4. Hydrophobic surfactant proteins SP-B and SP-C: molecular biology, structure and function (J.A. Whitsett, J.E. Baatz). 5. Surfactant protein SP-D (Y. Kuroki). 6. Morphologic aspects of the surfactant system (M.C. Williams). 7. Physical chemistry of pulmonary surfactant in the terminal air spaces (K.M.W. Keough). 8. Surfactant and lung mechanics (J. Goerke). 9. The role of pulmonary surfactant in transepithelial movement of liquid (D.V. Walters). 10. Surfactant and the pulmonary defense system (J.F. Van Iwaarden). 11. Metabolism of the pulmonary surfactant: model systems (W.J. Longmore, M.A. Moxley). 12. Biosynthesis of surfactant lipids (J.J. Batenburg). 13. Biosynthesis and intracellular processing of surfactant proteins (T.E. Weaver). 14. Surfactant secretion (R.J. Mason). 15. Catabolism and recycling of surfactant (A.H. Jobe, E.D. Rider). 16. Metabolism of surfactant lipids and proteins in the developing lung (A.M. Cockshutt, F. Possmayer). 17. Hormonal control of surfactant metabolism (M. Post, B.T. Smith). 18. Antenatal diagnosis of lung maturity (M. Hallman). 19. Animal models of neonatal surfactant dysfunction (B. Robertson). 20. Pathophysiology of neonatal surfactant insufficiency: clinical aspects (F.J. Walther, H.W. Taeusch). 21. Ventilation of the surfactant-deficient lung (R.A. deLemos, D.R. Gerstmann, J.J. Coalson). 22. Prevention of neonatal respiratory distress syndrome by pharmacological methods (R.A. Ballard, P.L. Ballard). 23. Pharmacology of exogenous surfactant (T. Fujiwara, B. Robertson). 24. Clinical experience with modified natural surfactant (B.T. Smith). 25. Clinical experience with artificial surfactants (C.J. Morley). 26. Adult respiratory distress syndrome: animal models (B. Lachmann, G.-J. Van Daal). 27. Surfactant inactivation in adult respiratory distress syndrome (B.A. Holm). 28. The adult respiratory distress syndrome: clinical aspects relevant to surfactant supplementation (R.G. Spragg et al.). 29. Toxicological aspects of the surfactant system (H.P. Haagsman). Subject index.

Verlagsort Oxford
Sprache englisch
Themenwelt Medizinische Fachgebiete Innere Medizin Pneumologie
Medizin / Pharmazie Medizinische Fachgebiete Pädiatrie
Studium 2. Studienabschnitt (Klinik) Pathologie
ISBN-10 0-444-89475-6 / 0444894756
ISBN-13 978-0-444-89475-5 / 9780444894755
Zustand Neuware
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