Signaling Pathways in Liver Diseases

Prof. J.-F. Dufour, hepatologist at the University of Bern, is internationally recognized for bridging basic science and clincial practice. Prof. P.-A. Clavien, head of visceral surgery University Hospital Zürich, is a world renown investigator in the field of liver ischemia/reperfusion injury. Prof. Clavien successfully lead multi-authored texts having already published 3 books as editor:  Malignant Liver Tumors, Blackwell Science Inc., May 1999 Medical Care of the Liver Transplant Patient (Killenberg/Clavien), Blackwell Science Inc. Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment (Clavien/Baillie),Blackwell Science Inc.

From the contents:
Part I Cell Types and Matrix: Hepatocytes.- Signaling Pathways in Biliary Epithelial Cells.- Stellate Cells.- Kupffer Cells.- Hepatic Sinusoidal Endothelial Cells.- Extracellular Matrix.- Part II Specific Signaling Pathways: IL-6/gp130/Stat3 - Vascular Endothelial Growth Factor Signaling.-. Insulin Pathway.- Nature and Functionof Hepatic Tumor Necrosis Factor-a Signaling.- The Fas/FasL Signaling Pathway.- TGF-ß and the Smad Pathway in Liver Fibrogenesis.- Interferon Signaling.- CD14 and Toll Receptor.- The Wnt/ß-Catenin Pathway.- Notch Signaling in Liver Disease.- Extracellular ATP: Emerging Roles of Purinergic Signaling.- Calcium Signaling.- MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival.- PI3K,PTEN and Akt.- TOR Signaling and Cell Growth Control.- Peroxisome Proliferator Activated Receptors.- Transcriptional Response to cAMP in the Liver.- Heme Oxygenase System.- Nitric Oxide.- Hypoxia-Inducible Factor-1 Signaling System.- Cyclins and CDKs in Liver Diseases.- Telomeres amd Telomerase: Distinctive Roles in Liver Regeneration, Cirrhosis and Carcinogenesis.- NF-kB.- Ceramide: Cell Regulation from a Lipid Perspective.- Apoptosis and Mitochondria.- Ubiquitin-Proteasome Pathway in the Pathogenesis of Liver Diseases.- Biological Clock in the Liver.- Part III Horizons: Pharmacogenomics of Cholestatic Liver Disease.- Proteomics of Signal Transduction Pathways.- Subject Index.