Endotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care

Silvia De Rosa is Anaesthesiologist and Intensivist at Department of Anaesthesia and Intensive Care, Santa Chiara Regional Hospital, APSS Trento, Italy; Centre for Medical Sciences - CISMed University of Trento, via S. Maria Maddalena, Italy. She is also a clinical researcher in Acute Kidney Injury and  Extracorporeal Organ Support at International Renal Research Institute of Vicenza.  She is a Next Committee Representative of the European Society of Intensive Care Medicine (ESICM) and Regional Councilor of "Italian Society of Anesthesia Analgesia and Intensive Care" (SIAARTI - Veneto Region). Her field of interest are Acute Kidney Injury and Extracorporeal Organ Support, Brain Trauma, Nutrition and Muscle Wasting, Airways Management. Co-investigator of the International registry on Acute Renal Replacement Therapy (Global-ARRT Registry).

Gianluca Villa is Associated Professor in Anaesthesiology, Intensive Care and Pain Medicine at the University of Florence. He is also a clinical researcher in Acute Kidney Injury and Extracorporeal Organ Support at International Renal Research Institute of Vicenza. Principal investigator of the International registry on Acute Renal Replacement Therapy (Global-ARRT Registry).

Endotoxin: Structure Source and Effects.- Pathophysiology of Endotoxic Shock.- Host Resistance to Endotoxic Shock.- Endotoxin and Organ Cross-talk.- Endotoxin Measurement in Septic Shock.- Clinical Management of Endotoxemia: Antibiotics.- Clinical Management of endotoxemia: volume support.- Clinical Management of Endotoxemia: Corticosteroids.- Clinical Management of Endotoxemia: Vasoactive and Cardiostimulant Drugs.- Clinical Management of Endotoxemia: Source Control.- Clinical Management of Endotoxemia: Treatment of DIC.- Clinical Management of Endotoxemia: Metabolic and Nutritional Support.- Strategies to Reduce Endotoxin Activities.- Extracorporeal Removal of Endotoxin.