Anion Channels and Transporters -

Anion Channels and Transporters

Christoph Fahlke (Herausgeber)

Buch | Hardcover
X, 362 Seiten
2024 | 1st ed. 2024
Springer International Publishing (Verlag)
978-3-031-51345-9 (ISBN)
160,49 inkl. MwSt
This book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues - often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems.

Preface.- Muscle chloride channels.- Adrenal anion channels - new roles in zona glomerulosa physiology and in the pathophysiology of primary aldosteronism.- ClC-K Kidney Chloride Channels : from structure to pathology.- Biophysical and pharmacological insights to CLC chloride channels and Transporters.- Function and regulation of the calcium-activated chloride channel anoctamin 1.- Structure and function of calcium-activated chloride channels and scramblases in TMEM16 family.- Structural basis for anion-selective Cys-loop receptor signal transduction and modulation.- Physiological functions of the volume regulated anion channel VRAC/LRRC8 and the proton-activated chloride channel PAC/TMEM206.- CFTR modulators: from mechanism to targeted therapeutics.- Structure, physiology, and pharmacology of chloride-dependent cation cotransporters.- SLC26 Anion Transporters.- Pharmacology of Na-dependent transporters of inorganic phosphate.- Simulation of fluoride anions in CLC proteins: from potent inhibition to selective transport.

Erscheinungsdatum
Reihe/Serie Handbook of Experimental Pharmacology
Zusatzinfo X, 362 p. 100 illus., 30 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 744 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Studium 1. Studienabschnitt (Vorklinik) Physiologie
Schlagworte anion channels • Anion Transport • Channelopathy • Cystic fibrosis • Myotonia • synaptic inhibition
ISBN-10 3-031-51345-2 / 3031513452
ISBN-13 978-3-031-51345-9 / 9783031513459
Zustand Neuware
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