Lung and Heart-Lung Transplantation

Joseph P. Lynch, David J. Ross

CLINICAL ASPECTS. Historical Overview of Lung and Heart-Lung Transplantation. IMMUNOLOGY OF TRANSPLANTATION: BASIC SCIENCE. Basic Immunologic Concepts Involved in Lung Transplantation. Allogeneic Recognition. Tolerance. Immunological Techniques for Assessing Alloreactivity in Potential Organ Recipients. CLINICAL ASPECTS. COPD and ?1-Antitrypsin Deficiency Emphysema. Cystic Fibrosis and Bronchiectasis. Pulmonary Hypertension. Lung Transplantation for Interstitial and Cystic Lung Diseases. Pediatric Lung Transplantation. Living Lobar Lung Transplantation. Controversies in Transplantation. Hear-Lung Transplantation. ORGAN ALLOCATION AND DONOR AVAILABILITY. Allocation of Donor Organs. European Experience. Australian Experience. Lung Preservation Techniques. Operative Techniques Utilized in Lung Transplantation. IMMUNOSUPPRESION: ACTION, EFFICACY, DRUG INTERACTIONS AND TOXICITIES. Cyclosporine, Tacrolimus, Sirolimus, Azathioprine, Mycophenolar, Mofetil, Corticosteroids. Lympholytic Agents. Novel and Future Approaches to Immunosuppression. COMPLICATIONS IN LUNG TRANSPLANTATION. Early Graft Dysfunction and Primary Graft Failure Following Lung Transplantation: Clinical Features, Recognition, and Treatment. Early Graft Dysfunction Following Lung Transplantation: Pathogenesis and Impact of Late Allograft Function. Airway Complications. INFECTIOUS COMPLICATIONS. Viral Infections Complication Lung and Solid Organ Transplantation. Invasive Fungal Infections Complicating Lung and Solid Organ Transplantation. Bacterial Infections. LUNG ALLOGRAFT REJECTION. Clinical Features of Acute Rejection: Incidence, Clinical Features, Management. Histology of Lung or Heart-Lung Allograft Rejection. Animal Models of Acute and Chronic Rejection. CHRONIC ALLOGRAFT REJECTION. Obliterative Bronchiolitis: Incidence, Clinical Features, Histology, Diagnosis, and Treatment. Pathogenesis of Bronchiolitis Obliterans Syndrome. Pulmonary Physiology Post-Transplant. Role of Surveillance Bronchoscopy. Thoracic Imaging Post Lung Transplant. LONG-TERM COMPLICATIONS OF LUNG TRANSPLANTATION. Cardiac, Renal, Hypertension, Lipids, Metabolic, Osteoporosis. Neoplasia Following Transplantation