Dubois' Lupus Erythematosus

HISTORY AND DEFINITIONS: Historical Background of Discoid & Systemic Lupus Erythematosus / Definition & Classification of Systemic Lupus Erythematosus / Environmental Aspects of Lupus / Epidemiology of Systemic Lupus Erythematosus PATHOGENESIS: Pathogenesis of Systemic Lupus Erythematosus / Genetics of Human Lupus / Genetics of Murine Systemic Lupus Erythematosus / Apoptosis / Interaction of T Cells with Cells of the Innate Immune System & B Cells in the Pathogenesis of SLE / Cytokines & Interferons in Lupus / B Cells in Systemic Lupus Erythematosus / Abnormalities in Immune Complex Clearance & Fcgamma Receptor Function / Complement & Systemic Lupus Erythematosus / Mechanisms of Acute Inflammation & Vascular Injury in Systemic Lupus Erythematosus / Idiotypes & Idiotype Networks / The Importance of Sex Hormones in Systemic Lupus Erythematosus / Neuroendocrine Immune Interactions: Principles & Relevance to Systemic Lupus Erythematosus / Animal Models of Systemic Lupus Erythematosus / Pathogenesis of Atherosclerosis in Lupus / Autoantigens & Defects in Immune Tolerance in Lupus AUTOANTIBODIES: Structure & Derivation of Antibodies & Autoantibodies / Antinuclear Antibodies: An Overview / Antibodies to DNA / Antibodies to Histones & Nucleosome-Related Antigens / Antibodies to Ro/SSA & La/SSB / Antibodies to Spliceosomal Components / The Lupus Anticoagulant & Antiphospholipid Antibodies / Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus THE SKIN IN LUPUS: Pathomechanisms of Cutaneous Lupus Erythematosus / Lupus-Specific Skin Disease (Cutaneous LE) / Lupus-Nonspecific Skin Disease CLINICAL ASPECTS OF LUPUS: Clinical Presentation of Systemic Lupus Erythematosus / The Musculoskeletal System / Cardiovascular Manifestations of Lupus / Pulmonary Manifestations of Systemic Lupus Erythematosus / Clinical Aspects of Vasculitis & Selected Cutaneovascular Manifestations of Systemic Lupus Erythematosus / The Nervous System / Psychopathology of Lupus & Neuroimaging / Head & Neck Findings in Systemic Lupus Erythematosus: Manifestations Involving the Eye, Ear & Larynx / Ocular, Aural & Oral Manifestations / Hematologic & Lymphoid Abnormalities in Systemic Lupus Erythematosus / Gastrointestinal & Hepatic Manifestations / Systemic Lupus Erythematosus in Childhood & Adolescence / Drug-Induced Lupus / Infections in Systemic Lupus Erythematosus / Serum & Plasma Protein Abnormalities & Other Clinical Laboratory Determinations in Systemic Lupus Erythematosus / Clinical Indices in the Assessment of Lupus / Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus / Differential Diagnosis & Disease Associations / Mixed Connective Tissue Disease & Overlap Syndromes / The Mother in Systemic Lupus Erythematosus / The Fetus in Systemic Lupus Erythematosus / Neonatal Lupus / Reproductive Issues in Women with Autoimmune Disease / Lupus Nephritis: Pathology & Pathogenesis / Clinical & Laboratory Features of Lupus Nephritis MANAGEMENT OF LUPUS: Principles of Therapy & Local Measures / Nonsteroidals & Salicylates for Systemic Lupus Erythematosus / Antimalarial Therapies / Systemic Glucocorticoid Therapy in Systemic Lupus Erythematosus / Immunosuppressive Drug Therapy / Nonpharmacologic & Complementary Therapeutic Modalities / Fibromyalgia in SLE & Use of Complementary & Alternative Medicine in SLE / Hormones & Gender-Related Issues / Clinical & Management Aspects of the Antiphospholipid Antibody Syndrome / Additional Therapies Used in the Management of Lupus / Adjunctive Measures & Issues: Allergies, Antibiotics, Vaccines & Disability / Issues in Drug Development in SLE: Clinical Trial Design, Outcome Measures & Biomarkers / Prognosis, Mortality & Morbidity in Systemic Lupus Erythematosus / Biologics & Stem Cell Therapies for Lupus Appendix I. A Patient's Guide to Lupus Erythematosus Appendix II. Lupus Resources