Postoperative Epidural Opioids

Joachim Chrubasik, Sigrun Chrubasik, Laurence Mather (Autoren)

Buch | Softcover

X, 119 Seiten

1993
Springer Berlin (Verlag)
978-3-540-56871-1 (ISBN)

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Epidural opioids are widely used in the management of post-operative pain. On the basis of an extensive review of theliterature the authors here present their own interpretationof current knowledge of howthe distribution and effectiveness of epidurallyadministeredopiods are fundamentally determined.They conclude that all opioids that arecurrently being used to treat postoperative epidural paincarry the potential risk of severeside effects if the dose regimens are not tailored to thepatient`s individual analgesic need.This book will serve to stimulate new ideas among painspecialistst.

Epidural and Intrathecal Space.- Anatomy.- Puncture of the Meninges.- Distribution of Solutions.- Determinants of Opioid Activity.- Physicochemical Properties.- Distribution and Elimination.- Opioid Receptors.- Opioid Pharmacokinetics After Epidural Administration.- Transfer Across the Meninges.- Uptake into the CSF.- Distribution within the CSF.- Elimination from CSF.- Uptake into Spinal Cord and Brain.- Uptake into Epidural Fat.- Vascular Uptake into the Systemic Circulation.- Elimination from Blood.- Summary.- Clinical Implications.- Onset Time of Analgesia.- Duration of Action.- Side-Effects.- Quality of Analgesia.- Summary.- Relative Analgesic Potencies.- Definition.- Quantitation from Postoperative Dose Requirements..- Interpretation.- Summary.- Risk-Benefit Evaluation.- Morphine.- Meperidine.- Methadone.- Alfentanil.- Fentanyl.- Sufentanil.- Buprenorphine.- Tramadol.- Summary.- References.

Erscheint lt. Verlag	25.8.1993
Zusatzinfo	X, 119 p. 9 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	215 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Notfallmedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Schmerztherapie
	Medizin / Pharmazie ► Pharmazie
Schlagworte	clinical iplications • klinische Auswirkungen • Opioid • pharmacocinetics • Pharmakokinetik • Risiko-Nutzen-Analyse • risk-benefit-evaluation • scientific bases • Wissenschaftliche Grundlagen
ISBN-10	3-540-56871-9 / 3540568719
ISBN-13	978-3-540-56871-1 / 9783540568711
Zustand	Neuware