Goodman & Gilman's The Pharmacological Basis of Therapeutics, Eleventh Edition

Laurence L. Brunton, PhD Professor of Pharmacology and Medicine University of California, San DiegoLaurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers. John S. Lazo, PhD Professor and Chairman Department of Pharmacology University of Pittsburgh School of Medicine Under John Lazo's leadership as Chairman, the Department of Pharmacology is regarded as one of the leading academic programs in the United States. He has published extensively in the field of cancer pharmacology. Keith Parker, MD, PhD Professor of Internal Medicine and Pharmacology Division of Endocrinology Department of Internal Medicine University of Texas Southwestern School of Medicine

SECTION I: GENERAL PRINCIPLES1. Pharmacokinetics and Pharmacodynamics2. Drug Transport/Drug Transporters3. Drug Metabolism4. Pharmacogenomics5. Principles of Therapeutics

SECTION II: DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems7. Muscarinic Receptor Agonists and Antagonists8. Anticholinesterase Agents 9. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia10. Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists11. 5-Hydroxytryptamine (Serotonin) Receptor Agonists and Antagonists

SECTION III: DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM12. Neurotransmission and the Central Nervous System13. History and Principles of Anesthesiology; General Anesthetics14. Local Anesthetics15. The Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium16. Hypnotics and Sedatives17. Introduction to Psychopharmacology: Drug Therapy of Depression and Anxiety Disorders18. Pharmacotherapy of Psychosis and Mania19. Drugs Effective in the Therapy of the Epilepsies20. Treatment of Central Nervous System Degenerative Disorders21. Opioid Analgesics 22. Ethanol23. Drug Addiction and Drug Abuse

SECTION IV: AUTACOIDS: DRUG THERAPY OF INFLAMMATIONIntroduction24. Histamine, Bradykinin, and Their Antagonists25. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor26. Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout27. Drugs Used in the Treatment of Asthma

SECTION V: DRUGS AFFECTING RENAL AND CARDIOVASCULAR FUNCTION28. Diuretics 29. Vasopressin and Other Agents Affecting the Renal Conservation of Water30. Renin and Angiotensin31. Drugs Used for the Treatment of Myocardial Ischemia32. Antihypertensive Agents and the Drug Therapy of Hypertension33. Pharmacological Treatment of Heart Failure34. Antiarrhythmic Drugs35. Drug Therapy for Hypercholesterolemia and Dyslipidemia

SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTION36. Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesopheageal Reflux Disease37. Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome38. Agents Used of Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease

SECTION VII: CHEMOTHERAPY OF PARASITIC INFECTIONS39. Drugs Used in the Chemotherapy of Protozoal Infections: Malaria40. Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections41. Drugs Used in the Chemotherapy of Helminthiasis

SECTION VIII: CHEMOTHERAPY OF MICROBIAL DISEASES42. Antimicrobial Agents: General Considerations43. Antimicrobial Agents (Continued): Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections44. Antimicrobial Agents: Penicillins, Cephalosporins, and Other b-Lactam Antibiotics45. Antimicrobial Agents: The Aminoglycosides46. Antimicrobial Agents: Protein-Synthesis Inhibitors and Miscellaneous Antibacterial Agents47. Antimicrobial Agents (Continued): Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy48. Antimicrobial Agents: Antifungal Agents49. Antimicrobial Agents: Antiviral Agents (Nonretroviral)50. Antimicrobial Agents: Antiretroviral Agents

SECTION IX: CHEMOTHERAPY OF NEOPLASTIC DISEASESIntroduction51. Antineoplastic Agents

SECTION X: DRUGS USED FOR IMMUNOMODULATION52. Imunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants

SECTION XI: DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS53. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins54. Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs

SECTION XII: HORMONES AND HORMONE ANTAGONISTS55. Pituitary Hormones and Their Hypothalamic Releasing Factors56. Thyroid and Antithyroid Drugs57. Estrogens and Progestins58. Androgens59. Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones60. Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas61. Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds

SECTION XIII: DERMATOLOGY62. Dermatological Pharmacology

SECTION XIV: OPHTHALMOLOGY63. Ocular Pharmacology

SECTION XV: TOXICOLOGY64. Principles of Toxicology; Treatment of Poisoning65. Poisoning; Heavy Metals and Heavy-Metal Antagonists

APPENDICESI. Principles of Prescription Order Writing and Patient ComplianceII. Design and Optimization of Dosage Regimens; Pharmacokinetic Data