Teratogenicity Testing
Springer-Verlag New York Inc.
978-1-0716-3624-4 (ISBN)
Authoritative and practical, Teratogenicity Testing: Methods and Protocols, Second Edition serves as an ideal guide to tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.
Updating an Overview of Teratology.- Guidelines on Development Toxicity Tests: Brief Insights.- Development Features on the Selection of Animal Models for Teratogenic Testing.- Virus as Teratogenic Agents.- The Future of the Teratogenicity Testing.- The First Steps on AOPs' Concepts, Development, and Applications in Teratology.- Machine Learning to Predict Teratogenicity: Theory and Practice.- Human Pluripotent Stem Cell-Based Assays to Predict Developmental Toxicity.- Developmental Toxicity Using the Rat Whole Embryo Culture.- A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs.- Teratogenic Effects of Drugs on Primary Lymphocytes Assessed by Flow Cytometry.- Assessment of the Teratogenic Effect of Drugs on the Chicken Embryo.- Daphnia magna as a Model Organism to Predict the Teratogenic Effect of Different Compounds.- Caenorhabditis elegans as an In Vivo Model Organism to Elucidate Teratogenic Effects.- Enduring Ethanol-Induced Behavioral Alterations in Caenorhabditis elegans after Developmental Lead Exposure.- Exploration of Teratogenic and Genotoxic Effects on Model Organism Drosophila melanogaster.- Ecotoxicological Assessment of Seaweed-Based Crop Biostimulant on Earthworm Eudrilus eugeniae Kinb.- Evaluation of the Ecotoxicology of Seaweed-Based Biopesticide Used in Combat of the Polyphagous Pest Using Eudrilus eugeniae Kinb.- Biochemical Studies to Understand Teratogenicity and Lethality Outcomes in Modified-FETAX.- Bioinformatics Methods for Transcriptome Analysis on Teratogenesis Testing.- Angiogenesis Assay for Live and Fixed Zebrafish Larvae.- High-Resolution Respirometry for the Assessment of Teratogenic Chemicals.- A Stereological Approach to Quantify Immunohistochemical Staining in Zebrafish Larvae.- Whole-Mount Immunohistochemical and Immunofluorescence Assays in Zebrafish Embryos.- Assessment of Developmental Neurotoxicity Using Semi-Automatic Behavior Analysis System for Zebrafish.- Behavioral Profiling of Zebrafish (Danio rerio) Larvae: Activity, Anxiety, Avoidance, and Startle Response.- Alcian Blue Staining for Chondrocranium Development in Zebrafish.- Protocol of Geometric Morphometrics for Teratogenicity Testing.- Biochemical Markers for Liver Injury in Zebrafish Larvae.- Cortisol Quantification for Assessing Stress-Induced Changes in Zebrafish Larvae.- Metabolomic Fingerprint Assay in Zebrafish Embryos.- Alkaline Comet Assay to Assess Genotoxicity in Zebrafish Larvae.- A Chromogenic Quantification of Protein Expression in Zebrafish Larvae.- Confocal Microscopy Technique in Teratogenicity Testing Using Zebrafish (Danio rerio) Embryos as Model.- Whole-Mount RNA In Situ Hybridization of Zebrafish Embryos.- Quantitative Real-Time PCR Method to Evaluate Gene Expression in Zebrafish Embryos.- Microarray Analysis to Determine Gene Expression Changes in Zebrafish Embryos.- Cell-Free DNA and Next-GenerationSequencing for Prenatal Diagnosis.
Erscheinungsdatum | 31.01.2024 |
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Reihe/Serie | Methods in Molecular Biology |
Zusatzinfo | 96 Illustrations, color; 17 Illustrations, black and white; XVI, 627 p. 113 illus., 96 illus. in color. With online files/update. |
Verlagsort | New York, NY |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Naturwissenschaften ► Biologie ► Zellbiologie | |
Schlagworte | Animal Models • developmental toxicity • Drug exposure • Embryo-fetal development • Pharmaceutical effects • Teratology screening |
ISBN-10 | 1-0716-3624-3 / 1071636243 |
ISBN-13 | 978-1-0716-3624-4 / 9781071636244 |
Zustand | Neuware |
Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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