Principles and Practice of Sleep Medicine Online

Meir H. Kryger, MD, FRCPC, Professor of Medicine, University of Connecticut, Director of Research and Education, Gaylord Hospital Sleep Medicine, Wallingford , Connecticut

I. Principles of Sleep Medicine Normal Sleep and Its Variations 1. History of Sleep Physiology and Medicine 2. Normal Human Sleep: An Overview 3. Normal Aging 4. Daytime Sleepiness and Alertness 5. Acute Sleep Deprivation 6. Chronic Sleep Deprivation 7. Phylogeny of Sleep Regulation 8. Mammalian Sleep Sleep Mechanisms 9. Brain Electrical Activity and Sensory Processing During Waking and Sleep States 10. REM sleep 11. Basic Mechanisms of Sleep-Wake States 12. Control of Motoneurons during sleep 13. Sleep-Promoting Mechanisms in Mammals Physiology in Sleep 14. Physiologic Regulation in Sleep 15. Cardiovascular Physiology: Central and Autonomic Regulation 16. Cardiovascular Physiology: The Peripheral Circulation 17. Respiratory Physiology: Central Neural Control 18. Respiratory Physiology: Control of Ventilation 19. Respiratory Physiology: Breathing in Normal Subjects 20. Respiratory Physiology: Sleep at High Altitudes 21. Host Defense 22. Endocrine Physiology 23. Gastrointestinal Physiology 24. Temperature Thermoregulation and Sleep 25. Neural Mechanisms of Sleep-Related Penile Erections Chronobiology 26. Master Circadian Clock: Master Circadian Rhythm 27. Circadian Rhythms in Mammals: Formal Properties and Environmental Influences 28. Anatomy of the Mammalian Circadian System 29. Physiology of the Mammalian Circadian System 30. Molecular Genetic Basis for Mammalian Circadian Rhythms 31. The Human Circadian Timing System and Sleep-Wake Regulation 32. Melatonin in the Regulation of Sleep and Circadian Rhythms 33. Sleep Homeostasis and Models of Sleep Regulation 34. Interaction of Sleep Homeostasis and Circadian Rhythmicity-- Dependent or Independent Systems? 35. Circadian Rhythms in Sleepiness, Alertness and Performance Pharmacology 36. Hypnotic Medications: Mechanisms of Action and Pharmacologic Effects 37. Clinical Pharmacology of Other Drugs Used as Hypnotics 38. Wake-Promoting Medications: Basic Mechanisms and Pharmacology 39. Wake-Promoting Medications: Efficacy and Adverse Effects 40. Drugs That Disturb Sleep and Wakefulness Psychobiology and Dreaming 41. Introduction to Dreams and their Pathology 42. The Content of Dreams: Methodologic and Theoretical Implications 43. Chronobiology of Dreaming 44. The Neurobiology of Dreaming 45. Dreaming as a Mood Regulation System in Normal and Abnormal Emotional States 46. Dreams and Nightmares in Posttraumatic Stress Disorder 47. Why We Dream II. Practice of Sleep Medicine Impact, Presentation, Diagnosis 48. Approach to the Patient with Disordered Sleep 49. Cardinal Manifestations of Sleep Disorders 50. Use of Clinical Tools and Tests in Sleep Medicine 51. Classification of Sleep Disorders 52. Epidemiology of Sleep Disorders 53. Sleep Medicine, Public Policy, and Public Health Disorders of Chronobiology 54. Introduction: Disorders of Chronobiology 55. Sleep Disruption in Jet Lag and Other Circadian Rhythm-Related Disorders 56. Shift Work: Basic Principles 57. Managing Work Schedules: An Alertness and Safety Perspective 58. Circadian Disorders of the Sleep-Wake Cycle Insomnia 59. Overview of Insomnia: Definitions, Epidemiology, Differential Diagnosis, and Assessment 60. Etiology and Pathophysiology of Insomnia 61. Psychological and Behavioral Treatments for Primary Insomnia 62. Psychological and Behavioral Treatments for Secondary Insomnias 63. Pharmacologic Treatment for Primary Insomnia Neurological Disorders 64. Narcolepsy: Pharmacology, Pathophysiology, and Genetic Predisposition 65. Narcolepsy: Diagnosis and Management 66. Idiopathic Hypersomnia 67. Parkinsonism 68. Sleep and Stroke 69. Sleep and Neuromuscular Disease 70. Restless Legs Syndrome and Periodic Limb Movements During Sleep 71. Alzheimer's Disease and other Dementias 72. Epilepsy, Sleep, and Sleep Disorders 73. Other Neurological Disorders Parasomnias 74. NREM Sleep-Arousal Parasomnias 75. REM Sleep Parasomnias 76. Other Parasomnias 77. Nightmares and Other Common Dream Disturbances 78. Disturbed Dreaming in Medical Conditions 79. Sleep Bruxism 80. Violent Parasomnias: Forensic Medicine Issues Sleep Breathing Disorders 81. Central Sleep Apnea 82. Anatomy and Physiology of Upper Airway Obstruction 83. Snoring and Upper Airway Resistance 84. Genetics of Obstructive Sleep Apnea 85. Cognition and Performance in Patients with Obstructive Sleep Apnea-Hypopnea 86. Sleep Apnea and Metabolic Dysfunction 87. Clinical Features and Evaluation of Obstructive Sleep Apnea-Hypopnea Syndrome and the Upper Airway Resistance Syndrome 88. Medical Therapy of Obstructive Sleep Apnea-Hypopnea Syndrome 89. Continuous Positive Airway Pressure for Obstructive Sleep Apnea-Hypopnea 90. Surgical Management for Sleep Disordered Breathing 91.Oral Appliances for Sleep Disordered Breathing 92. Management of Obstructive Sleep Apnea-Hypopnea Syndrome: Overview 93. Asthma and Chronic Obstructive Pulmonary Disease 94.Restrictive Lung Disorders 95 Nocturnal Noninvasive Positive Pressure Ventilation in the Treatment of Chronic Respiratory Failure Cardiovascular Disorders 96. Sleep and Cardiovascular Disease: Present and Future 97. Sleep-Related Cardiac Risk 98. Cardiac Arrythmogenesis During Sleep: Mechanisms, Diagnosis and Therapy 99. Cardiovascular Effects of Sleep-Related Breathing Disorders 100. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea 101. Coronary Artery Disease and Obstructive Sleep Apnea 102. Heart Failure Other Medical Disorders 103. Sleep and Fatigue in Cancer Patients 104. Fibromyalgia and Chronic Fatigue Syndrome 105.Endocrine Disorders 106. Pain and Sleep Interaction 107.Gastrointestinal Disorders Women's Health 108. The Menstrual Cycle and Women's Sleep and Circadian Rhythms 109. Pregnancy and Postpartum 110. Menopause Psychiatric Disorders 111. Anxiety Disorders 112. Mood Disorders 113. Schizophrenia 114. Sleep and Eating Disorders 115. Medication and Substance Abuse Methodology 116. Monitoring and Staging Human Sleep 117. Monitoring Techniques for Evaluating Suspected Sleep-disordered Breathing in Adults 118. Assessment of Sleep-related Erections 119. Assessment Techniques for Insomnia 120. Evaluating Sleepiness 121. Light Therapy 122. Neurological Monitoring Techniques 123. Gastrointestinal Monitoring Techniques 124. Actigraphry 125. Chronobiological Monitoring Techniques