Kelley's Textbook of Rheumatology

VOLUME I Section I: Structure and Function of Bone, Joints, and Connective Tissue 1. Biology of the Normal Joint 2. Collagen and Elastin 3. Matrix Glycoproteins and Proteoglycans in Cartilage 4. Proteinases and Matrix Degradation 5. Muscle: Anatomy, Physiology, and Chemistry 6. Biomechanics of Joints Section II: Cells Involved in Autoimmune Diseases and Inflammation 7. Antigen Presenting Cells 8. Innate Immunity 9. T Lymphocytes 10. B Cells 11. Synoviocytes 12. Fibroblast Function and Fibrosis 13. Chondrocytes 14. Neutrophils and Eosinophils 15. Platelets and Rheumatic Diseases Section III: Effector mechanisms in Autoimmunity and Inflammation 16. Autoimmunity 17. Genetics of Rheumatic Diseases 18. Signal Transduction in Rheumatic Diseases 19. Rheumatoid Factor 20. Antinuclear Antibodies 21. Immune Complexes 22. Complement System 23. Prostaglandins, Leukotrienes, and Related Compounds 24. Recruitment of Cells and Angiogenesis 25. Cytokines 26. Apoptosis Section IV: Broad Issues in the Approach to Rheumatic Diseases 27. Epidemiology of the Rheumatic Diseases 28. Economic Burden of Rheumatic Diseases 29. Assessment of Health Outcomes 30. Development, Execution, and Analysis of Clinical Trials 31. Occupational and Recreational Musculoskeletal Disorders 32. Alternative Care for Arthritis and Related Musculoskeletal Diseases Section V: Evaluation of Generalized and Localized Symptoms 33. History and Physical Examination of the Musculoskeletal System 34. Monarticular Arthritis 35. Polyarticular Arthritis 36. Fibromyalgia: A Chronic Pain Syndrome 37. Neck Pain 38. Shoulder Pain 39. Low Back Pain 40. Hip and Knee Pain 41. Ankle and Foot Pain 42. Hand and Wrist Pain 43. Temporomandibular Joint Pain 44. The Eye and Rheumatic Disease 45. The Skin and Rheumatic Diseases Section VI: Diagnostic Tests and Procedures in Rheumatic Diseases 46. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology 47. Arthrocentesis and Injection of Joints and Soft Tissues 48. Arthroscopy 49. Laboratory Evaluation of Inflammatio 50. Biological Markers 51. Imaging of Bones, Joints, and Connective Tissue Section VII: Modalities of Therapy in Rheumatic Diseases: Non-pharmacologic Interventions 52. Education of Patients 53. Psychosocial Management of the Rheumatic Diseases 54. Nutrition and Rheumatic Diseases 55. Rehabilitation of Patients with Rheumatic Diseases Section VIII: Drug Therapy for Rheumatic Diseases 56. Nonsteroidal Anti-inflammatory Drugs 57. Glucocorticoid Therapy 58. Second-line Agents: Sulfasalazine, Anti-malarials, Gold Salts, and D-penicillamine 59. Methotrexate, Leflunomide, and Combination Therapies 60. Immunoregulatory Drugs 61. Anti-cytokine Therapies 62. Emerging Therapies 63. Pharmacology and the Elderly 64. Chronic Musculoskeletal Pain VOLUME 2 Section IX: Rheumatoid Arthritis 65. Etiology and Pathogenesis of Rheumatoid Arthritis 66. Clinical Features of Rheumatoid Arthritis 67. Treatment of Rheumatoid Arthritis 68. Felty's Syndrome 69. Sjogren's Syndrome Section X: Spondyloarthropathies 70. Ankylosing Spondylitis 71. Reiter's Syndrome, Undifferentiated Spondyloarthropathy and Reactive Arthritis 72. Psoriatic Arthritis 73. Enteropathic Arthritis Section XI: Systemic Lupus Erythematosus and Related Syndromes 74. Pathogenesis of SLE 75. Clinical Manifestations of Systemic Lupus Erythematosus 76. Management of Systemic Lupus Erythematosus 77. Antiphospholipid Antibody Syndrome Section XII: Mixed Connective Tissue Disease, Scleroderma, and Inflammatory Myopathies 78. Mixed Connective Tissue Disease and Other Overlap Syndromes 79. Scleroderma and Raynaud's Disease 80. Inflammatory Diseases of Muscle and Other Myopathies Section XIII: Vasculitis 81. The Classification and Epidemiology of Systemic Vasculitis 82. Giant Cell Arteritis, and Polymyalgia Rheumatica, 83. Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis: Wegener's Granulomatosis, Microscopic Polyangitis and Churg Strauss Syndrome 84. Polyarteritis and Related Disorders 85. Cutaneous Small-Vessel Vasculitis 86. Behcet's Disease Section XIV: Crystal-induced Inflammation 87. Gout and Hyperuricemia 88. Diseases Associated with Articular Deposition of Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate Crystals Section XV: Bone, Cartilage, and Heritable Connective Tissue Disorders 89. Biology, Physiology, and Morphology of Bone 90. Metabolic Bone Disease 91. Pathogenesis of Osteoarthritis 92. Clinical Features of Osteoarthritis 93. Management of Osteoarthritis 94. Relapsing Polychondritis 95. Heritable Disorders of Structural Proteins Section XVI: Rheumatic Diseases of Childhood 96. Juvenile Rheumatoid Arthritis 97. Systemic Lupus Erythematosus, Juvenile Dermatomyositis, Scleroderma and Vasculitis Section XVII: Infection and Arthritis 98. Arthritis Caused by Bacteria or Their Components 99. Lyme Disease 100. Mycobacterial and Fungal Infections 101. Rheumatic Manifestations of Human Immunodeficiency Virus Infection 102. Viral Arthritis 103. Acute Rheumatic Fever and Post-Streptoccocal Arthritis XVIII: Arthritis Accompanying Systemic Diseases 104. Amyloidosis 105. Sarcoidosis 106. Iron Storage Disease 107. Hemophilic Arthropathy 108. Hemoglobinopathies and Arthritis 109. Arthritis Accompanying Endocrine and Metabolic Disorders 110. Hypertrophic Osteoarthropathy 111. Musculoskeletal Syndromes in Malignancy 112. Familial Auto-inflammatory Syndromes XIX: The Common Ground of Rheumatology and Orthopaedic Surgery 113. Tumors and Tumor-like Lesions of Joints 114. Osteonecrosis 115. Introduction to Surgical Management of Patients with Arthritis 116. Principles of Reconstructive Surgery for Arthritis