Controlled Drug Delivery Systems

Professor Emmanuel C. Opara earned his PhD in Medical Sciences from the University of London, England. He came to the USA in 1984 as a World Health Organization (WHO) Fellow in Endocrinology/Metabolism at the Mayo Clinic in Rochester, Minnesota. He later moved to the National Institute of Diabetes, Digestive and Kidney diseases (NIDDK) of the National Institutes of Health in Bethesda Maryland, where he served as a Visiting Fellow from 1986 to 1988 prior to accepting a faculty position in the Department of Surgery at Duke University Medical Center, Durham, North Carolina. In 2003, after 15 years at Duke, he was appointed Research Professor at the Pritzker Institute of Biomedical Science and Engineering at the Illinois Institute of Technology (IIT), Chicago while serving as Senior Investigator in the Human Islet Transplant Program at the Pritzker School of Medicine of the University of Chicago. He currently serves as Professor of Regenerative Medicine and Biomedical Engineering at the Wake Forest School of Medicine and the Graduate Program Director at the Wake Forest University Campus of the Joint Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences (SBES).

Foreword - David Williams; Preface – Emmanuel C Opara; Chapter 1: Introduction – Approaches to controlled drug delivery - Antonios Mikos; Chapter 2: Chemical modifications of alginate for controlled drug delivery and regenerative medicine - Mark E. Welker; Chapter 3: Hydrogel systems for delivery and release of cell-secreted and synthetic therapeutic products – Aleks Skardal; Chapter 4: The effect of glutathione incorporated as chain transfer agent in thermo-sensitive hydrogels for controlled release of therapeutic proteins – V Perez-Luna; Chapter 5: Controlled vaccine delivery – Kevin McHugh; Chapter 6: Controlled release of hormone by pellet implants – Sivanandane Sittadjody; Chapter 7: Delivery of ovarian hormones for bone health - Justin Saul; Chapter 8: Controlled delivery models of bioactive factors for the maturation of engineered tissues -Ashkan Shafiee & Atala; Chapter 9: Controlled delivery of angiogenic proteins – Eric M Brey; Chapter 10: Controlled therapeutic delivery in wound healing – Sean Murphy; Chapter 11: Leveraging plasma insulin estimates and wearable technologies to develop an automated insulin delivery system in Type 1 diabetes – A Cinar; Chapter 12: New developments in oral insulin delivery – Emmanuel C Opara; Chapter 13: Insulin delivery by a bioartficial pancreas– Will Kendall; Chapter 14: Transdermal drug delivery - Brahmeshwar Mishra; Chapter 15: Mucoadhesive chitosan-based nanoparticles for oral drug delivery - Shirui Mao; Chapter 16: Liposome-based delivery of therapeutic agents –Eneida de Paula; Chapter 17: Targeted intestinal delivery of probiotics – Emmanuel C. Opara