Intraoperative Flow Cytometry (eBook)

This book describes intraoperative flow cytometry in solid tumours. Intraoperative flow cytometry is an innovative technique for assessing tumour margins and grade of malignancy intraoperatively. The authors have been working on this procedure for more than 14 years and have introduced it in the surgery of intracranial tumours, breast cancer, liver cancer and  head and neck neoplasms, as described in the book. A detailed description of the main pathological findings will be followed by an explanation of the intraoperative flow cytometry's role.  In each chapter, information will be provided to stimulate further research on this topic. The book will also include new topics that have not been published till now.

The book is aimed at neurosurgeons, general surgeons, ENT specialists, breast surgeons, radiologists, pathologists, oncologists, biologists, biochemists and scientists working with on flow cytometry.

Georgios Alexiou is an Associate Prof. of Neurosurgery  at the University Hospital of Ioannina, Greece. He undertook his neurosurgical training at ''Agia Sofia'' Children's Hospital in Athens and at the University Hospital of Ioannina, Greece. After finishing his residency, he received the EANS Spine Fellowship award and worked as a Clinical Fellow in the Department of Neurosurgery in Leeds Teaching Hospital, UK. He then received the AANS International Travelling Fellowship in Pediatric Neurosurgery award at the Department of Neurosurgery in Boston Children's Hospital, Harvard Medical School. Dr. Alexiou worked as a consultant at the Gamma Knife Center at the University Hospital La Timone in Marseille, France. He has a Master degree in Biotechnology and Public Health. Dr. Alexiou worked as a postdoctoral research fellow at MD Anderson Cancer Center in Houston Texas and is also working on basic research at the Neurosurgical Institute in Ioannina, Greece.  His primary research interests are pediatric neurosurgery, advanced imaging and radiotherapy techniques to improve the outcomes of glioma patients, intraoperative flow cytometry for brain tumor surgery and on the discovery and validation of novel chemotherapeutic agents for glioma treatment.

Georgios Vartholomatos is a BsC in Biochemistry and PhD in Biochemistry and Molecular Genetics. He has been a visiting post-graduate at the University of California, Berkeley. He is currently the Scientific Correspondent of the Unit of Molecular Biology and Translation Flow Cytometry, University Hospital of Ioannina, Greece, which is reference centre in Epirus region for the diagnosis of haematology malignancies and autoimmune diseases using flow cytometry. He is the Coordinator of the Research Working Group of intraoperative Flow Cytometry (iFC) and has a solid experience in the use of flow cytometry as a diagnostic and research tool, being author of several publications that present innovative flow-cytometric approaches in clinical practice. He is deeply involved in the development and clinical implementation of novel diagnostic intraoperative tools for the cell cycle DNA analysis and immunophenotype in different types of solid tumors.