Radiopharmaceutical Therapy and Dosimetry

Robert Hobbs is an associate professor and medical physicist in the department of radiation oncology at Johns Hopkins and is the chair of the AAPM radiopharmaceutical therapy subcommittee. His research interests include alpha-particle dosimetry and combination therapies with radiopharmaceutical therapy and external beam. Joseph O'Donoghue is an attending physicist at Memorial Sloan Kettering Cancer Center. His work focuses on the use of quantitative analysis to study radiation dosimetry, biological response assessment, and clinical utility of radiolabeled molecules for imaging and therapy of cancer. Jessica Clements is an imaging medical physicist and the radiation safety officer at The University of Vermont Medical Center. She volunteers with the AAPM, ABR, ACR , and CRC PD on topics ranging from radiological protection to government and regulatory affairs.

Chapter 1 Current FDA-Approved RPTs and Their Uses
Nichole M. Maughan and Alireza Ehtenham
Chapter 2 Nuclear Regulatory Commission Regulations and Medical Event Reporting
Katie Tapp
Chapter 3 Dosimetry in Radiopharmaceutical Therapy: One Physician's Perspective
Chaitanya Divgi
Chapter 4 Dose Calibrator QA, Traceability, and Uncertainty
Denis E. Bergeron and Brian E. Zimmerman
Chapter 5 Patient Release Criteria and Instructions
Wesley E. Bolch and Adam Kesner
Chapter 6 Radiation Safety in Radiopharmaceutical Therapy
Jessica Clements
Chapter 7 Concepts and Requirements for SPECT/CT Quantification
Eric C. Frey
Chapter 8 PET/CT Quantitation and Uncertainties
Denis E. Bergeron and Brian E. Zimmerman
Chapter 9 Calibration for Quantitative SPECT/CT
Eric C. Frey
Chapter 10 Quality Assurance for SPECT/CT: Making the Transition from Diagnostic to Therapeutic Applications
Stephen A. Graves
Chapter 11 Surrogate Imaging Dosimetry
Adam Leon Kesner
Chapter 12 Principles of Prospective Treatment Planning
Robert F. Hobbs
Chapter 13 The MIRD Schema and Computational Human Phantoms
Wesley E. Bolch
Chapter 14 Yttrium-90 Microspheres: Treatment Planning using the MIRD Formalism
Diane Alvarez and Robert F. Hobbs
Chapter 15 Curve Fitting
Joe O'Donoghue
Chapter 16 Uncertainties and Error Propagation
Jonathan I. Gear
Chapter 17 Consistency and Standardization
Rachel Barbee and David Barbee
Chapter 18 Principles of Voxelized Dosimetry
Stephen A. Graves
Chapter 19 Multiple Timepoint Image Registration
Bryan Bednarz
Chapter 20 Uncertainties and Relative Merits of Voxelized vs. Organ-Level Dosimetry
Jonathan I. Gear
Chapter 21 Bio-Effect Modeling in Radiopharmaceutical Therapy
Robert F. Hobbs
Chapter 22 Standardization and ICRU Report 96
Roger W. Howell
Chapter 23 Radiopharmaceutical Therapy Reimbursement: an Evolving Landscape in the United States
Russell Tarver and Gerald White