Phospholipases in Physiology and Pathology

Dr. Sajal Chakraborti, PhD, DSc is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did post-doctoral research at the Johns Hopkins Medical Institution, Baltimore; New York Medical College, New York; the University of Utah Health Sciences Center, Salt Lake City, Utah; and the University of Florida, Gainesville, Florida. He has over 35 years teaching and independent research experience in Biochemistry, Molecular Physiology and Cell Biology. He has published over 110 original research articles, 25 review articles and book chapters, and also edited twelve books published by Springer.

A. Implication in Inflammation 

1. Role and Regulation of Phospholipase D2 in inflammatory diseases     2. Cytosolic Phospholipase A2 (PLA2G4) –mediated oxidative and inflammatory responses in neurodegenerative diseases

3. Modulation of Phospholipases by Phenolic Compounds: Novel Targets in the Management of Inflammatory Diseases 

4. Phospholipase A2 superfamily and their role in chronic inflammatory conditions with relation to adjuster cells    5. Role of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) in neuroinflammation and neurodegeneration 

6. Role role of phospholipase A2 in vascular health and disease    7. Phospholipase A2 as modulator of inflammation    8. Inflammatory Effects of Phospholipases A2 Present in Snake Venom of the Genus Bothrops

9. Lipoprotein-associated phospholipase A2: Antioxidant and inflammatory roles

10. Phospholipases and membrane remodeling in inflammation and neoplasia

11. Phospholipase A2 mediated regulation of inflammation and apoptosis

B. Implication in Apoptosis    12. Role of platelet-activating factor acetylhydrolase on the inflammatory and apoptotic processes in atherosclerosis    13. Functional role of phospholipase D in apoptosis and cancer 

14.  Role of cytosolic phospholipase A2 in TNF-a and caspase-mediated apoptosis 

15. Phospholipases: Insights into the potential role of cell death

16. Calcium- dependent and – independent phospholipases and apoptosis

C. Implication in Gene Expression and Non-coding RNAs

17. Influence of phospholipase on expression of metallothionein to repair cells 

18. Epigenetic tools of phospholipase A1 and A2 in gene therapy    19. Role of non-coding RNAs phospholipases mediated diseases 

20. The genetics of Phospholipase induced redox signaling in neuroinflammation and neuronal diseases

21. Signal transduction and regulation of phospholipases during tumorigenic processes 

22. Functions and gene expression alterations of phospholipase C in gemetes 

23. Highlighting the role of phospholipase A2 and non-coding RNA in colorectal cancer 

24. Long non-coding RNAs: a new frontier of ameliorative potentiality on cytosolic phospholipase A2 (cPLA2) mediated non- alcoholic fatty liver disease

25. Crosstalk between Phospholipases and non-coding RNAs in cancer 

26. Relationship between Phospholipases and lncRNAs during the onset of diseases    27. Epigenetic signatures in phospholipase receptor genes predict cancer initiation and therapeutic progression