The Physics and Radiobiology of Fast Neutron Beams
Institute of Physics Publishing (Verlag)
978-0-85274-093-4 (ISBN)
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Over fifty years have passed since the first patient was treated with fast neutrons, but this form of therapy is still a matter of bitter dispute. Neutron generators have been installed in many countries and now patients can be treated with equipment that is technically similar to modern megavoltage x-ray equipment.
The Physics and Radiobiology of Fast Neutron Beams presents a full discussion of the physical and radiobiological factors governing the production and use of fast neutron beams for therapy. The book discusses vastly improved neutron generators, advances in the standardization of dosimetric methods, and the specification of radiation quality. In addition, it explores nuclear methods of analysis, particularly neutron activation analysis in vivo. Influencing the place of radiotherapy with neutrons and other heavy particles, the radiobiological factors governing the treatment of cancer with radiation are examined. The author also studies the radiation hazard of neutrons, a matter of importance in the use of neutrons for chemical analysis in vivo.
The Physics and Radiobiology of Fast Neutron Beams will be a valuable introduction to the subject for radiotherapists, medical physicists, radiographers, and radiobiologists new to the field. The book is also a useful summary of current knowledge for those already established in the use of fast neutrons for medical purposes.
PRODUCTION OF NEUTRON BEAMS
Basic properties of the neutron
Neutron sources
Comparison of generators for neutron therapy
Comparison of generators for nuclear methods of analysis (activation)
NEUTRON INTERACTIONS AND KERMA
Cross sections
Kerma
Neutron spectra in terms of soft-tissue kerma
DOSIMETRY
Methods of dosimetry
Principles of mixed-field dosimetry
Absolute instruments
Relative instruments: ionization chambers
Separation of neutron and gamma-ray components
Miscellaneous dosimetric methods
Neutron dosimetry intercomparisons
PENETRATION IN TISSUE
Phantom materials
Measurement of dose distributions
Examples of dose distributions
Backscatter
Gamma radiation
Target thickness and filtration
Transition dose
Inhomogeneities
SHIELDING, COLLIMATION, AND RADIATION PROTECTION
Doses far outside the beam
Induced radioactivity
Doses received by staff due to activation
Room shielding
Protection measurements
RADIATION QUALITY
Neutron spectra
Quality from secondary charged particles
RADIOBIOLOGY
General concepts
RBE and neutron energy
Chemical modifiers of radiation response
RBE and position in the cell cycle
Repair of damage after photons and neutrons
RBE and dose level
RBE in relation to tissue and end-point
Tumors
RBE and secondary charged-particle equilibrium
The gamma-ray component
NEUTRON THERAPY
Effects of hypoxia
Radioresistant tumors
Growth rates
Selection of cases
Treatment schedules
Other forms of high-LET radiation
THE RADIATION HAZARD OF NEUTRONS
Introduction
Quality factor
Use of chromosome aberrations to assess dose-equivalent
RBE values for life-shortening and carcinogenesis
Doses and risks to patients investigated by nuclear methods of analysis (activation)
SUMMARY AND CONCLUSIONS
REFERENCES
INDEX
| Erscheint lt. Verlag | 1.10.1989 |
|---|---|
| Verlagsort | London |
| Sprache | englisch |
| Maße | 216 x 279 mm |
| Gewicht | 658 g |
| Themenwelt | Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Nuklearmedizin |
| Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie | |
| ISBN-10 | 0-85274-093-X / 085274093X |
| ISBN-13 | 978-0-85274-093-4 / 9780852740934 |
| Zustand | Neuware |
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