Fishman's Manual of Pulmonary Diseases and Disorders

Part One PERSPECTIVES Volume 1 Chapter 1 Milestones in the History of Pulmonary Medicine Part Two SCIENTIFIC BASIS OF LUNG FUNCTION IN HEALTH AND DISEASE Section 1 Architecture for Normal Lung Function Chapter 2 Functional Design of the Human Lung for Gas Exchange Chapter 3 The Respiratory Muscles Chapter 4 Cellular Mechanisms of Lung Development Chapter 5 Development and Growth of the Lung Chapter 6 Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Physiology and Pharmacology Chapter 7 Surfactant and Associated Proteins Chapter 8 Transport Function of Airway Epithelia and Submucosal Glands Chapter 9 Nonrespiratory Functions of the Lungs Section 2 Physiological Principles of Normal Lung Function Chapter 10 Pulmonary Mechanics Chapter 11 Control of Ventilation Chapter 12 Ventilation, Pulmonary Blood Flow, and Ventilation-Perfusion Relationships Chapter 13 Diffusion, Chemical Reactions Involving Respiratory Gases, and Diffusing Capacity Chapter 14 Blood-Gas Transport Chapter 15 Acid-Base Balance Section 3 The Lungs in Different Physiological States Chapter 16 Exercise, Integration, and Adaptation Chapter 17 Breathing during Exercise Chapter 18 The Lungs in Pregnancy Chapter 19 Aging of the Respiratory System Section 4 Lung Immunology Chapter 20 Pulmonary Defense Mechanisms against Infections Chapter 21 Lymphocyte- and Macrophage-Mediated Inflammation in the Lung Chapter 22 Mast Cells and Eosinophils Chapter 23 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency Section 5 Lung Injury and Repair Chapter 24 Cytokines and Chemokines in Lung Inflammation and Injury Chapter 25 Leukocyte Accumulation in the Lung Chapter 26 Nitric Oxide and Lung Injury Chapter 27 The Pathogenesis of Pulmonary Fibrosis Part Three SYMPTOMS AND SIGNS OF RESPIRATORY DISEASE Section 6 Clinical Approach to the Patient Chapter 28 Approach to the Patient with Respiratory Symptoms Chapter 29 Pulmonary Cutaneous Disorders Chapter 30 Pulmonary-Systemic Interactions Section 7 Diagnostic Procedures Chapter 31 Principles of Effective Care Chapter 32 Radiographic Evaluation of the Chest Chapter 33 Pulmonary Cytopathology Chapter 34 Angiographic Techniques in the Evaluation and Management of Suspected Pulmonary Disease Chapter 35 Scintigraphic Evaluation of Pulmonary Disease Chapter 36 Pulmonary Function Testing Chapter 37 Principles and Applications of Cardiopulmonary Exercise Testing Chapter 38 Bronchoscopy, Transthoracic Needle Aspiration, and Related Procedures Chapter 39 Thoracoscopy Chapter 40 Perioperative Respiratory Considerations in the Surgical Patient Chapter 41 Impairment and Disability Evaluation in Lung Disease Part Four OBSTRUCTIVE LUNG DISEASES Section 8 Chronic Obstructive Pulmonary Disease Chapter 42 Chronic Obstructive Lung Disease: Overview Chapter 43 Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, and Pathogenesis Chapter 44 Chronic Obstructive Pulmonary Disease: Clinical Course and Management Chapter 45 Cigarette Smoking and Disease Chapter 46 Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders Section 9 Asthma Chapter 47 The Biology of Asthma Chapter 48 Asthma: Epidemiology Chapter 49 Aspirin- and Exercise-Induced Asthma Chapter 50 Asthma: Clinical Presentation and Chapter 51 Allergic Bronchopulmonary Aspergillosis and Hypersensitivity Reactions to Fungi Section 10 Other Obstructive Disorders Chapter 52 Upper Airway Obstruction Chapter 53 Cystic Fibrosis Chapter 54 Bronchiolitis Chapter 55 Bullous Diseases of the Lungs Part Five OCCUPATIONAL AND ENVIRONMENTAL DISORDERS Section 11 Occupational Disorders Chapter 56 Occupational Lung Disorders: General Principles and Approaches Chapter 57 Asbestos-Related Lung Disease Chapter 58 Chronic Beryllium and Hard-Metal Lung Disease Chapter 59 Coal Workers' Lung Diseases and Silicosis Chapter 60 Occupational Asthma, Byssinosis, and Industrial Bronchitis Chapter 61 Toxic Inhalations Section 12 Environmental Disorders Chapter 62 Indoor and Outdoor Air Pollution Chapter 63 Pulmonary Adaptation and Clinical Disorders Related to High Altitude Chapter 64 Diving Injuries and Air Embolism Chapter 65 Thermal Lung Injury and Acute Smoke Inhalation Part Six DRUG-INDUCED LUNG DISEASES Chapter 66 Pulmonary Toxicity Associated with Chemotherapeutic Agents Chapter 67 Drug-Induced Lung Disease due to Nonchemotherapeutic Agents Part Seven INTERSTITIAL AND INFLAMMATORY LUNG DISEASES Section 13 Immunologic and Interstitial Diseases Chapter 68 Interstitial Lung Disease: A Clinical Overview and General Approach Chapter 69 Systemic Sarcoidosis Chapter 70 Idiopathic Pulmonary Fibrosis Chapter 71 Hypersensitivity Pneumonitis Chapter 72 Radiation Pneumonitis Chapter 73 Pulmonary Manifestations of the Collagen Vascular Diseases Chapter 74 The Eosinophilic Pneumonias Section 14 Depositional and Infiltrative Disorders Chapter 75 Depositional Diseases of the Lungs Chapter 76 Pulmonary Histiocytosis X Chapter 77 Pulmonary Lymphangioleiomyomatosis Chapter 78 The Lungs in Patients with Inborn Errors of Metabolism Part Eight ALVEOLAR DISEASES Chapter 79 Alveolar Hemorrhage Syndromes Chapter 80 Mechanisms of Aspiration Disorders Chapter 81 Pulmonary Alveolar Proteinosis Part Nine DISORDERS OF THE PULMONARY CIRCULATION Chapter 82 The Pulmonary Circulation Chapter 83 Pulmonary Hypertension and Cor Pulmonale Chapter 84 Pulmonary Thromboembolic Disease Chapter 85 Pulmonary Edema Chapter 86 Pulmonary Vasculitis Chapter 87 Pulmonary Arteriovenous Malformations Part Ten DISORDERS OF THE PLEURAL SPACE Chapter 88 Pleural Fluid Dynamics and Effusions Chapter 89 Nonmalignant Pleural Effusions Chapter 90 Malignant Pleural Effusions Chapter 91 Pneumothorax Chapter 92 Malignant Mesothelioma and Other Primary Pleural Tumors Part Eleven DISEASES OF THE MEDIASTINUM Chapter 93 The Mediastinum: Overview, Anatomy, and Diagnostic Approach Chapter 94 Nonneoplastic Disorders of the Mediastinum Chapter 95 Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies Chapter 96 Acquired Lesions of the Mediastinum: Benign and Malignant Part Twelve DISORDERS OF THE CHEST WALL, DIAPHRAGM, AND SPINE Chapter 97 Nonmuscular Diseases of the Chest Wall Chapter 98 Effects of Neuromuscular Diseases on Ventilation Chapter 99 Pulmonary Rehabilitation in Neuromuscular Diseases Part Thirteen SLEEP AND SLEEP DISORDERS Chapter 100 The Stages of Sleep Chapter 101 Changes in the Cardiorespiratory System during Sleep Chapter 102 Sleep Apnea Syndromes Chapter 103 Differential Diagnosis and Evaluation of Sleepiness Part Fourteen SURGICAL ASPECTS OF PULMONARY MEDICINE Chapter 104 Perioperative Care of the Patient Undergoing Lung Resection Chapter 105 Thoracic Trauma Chapter 106 Lung Transplantation Part Fifteen NEOPLASMS OF THE LUNGS Section 15 Cancer of the Lungs Chapter 107 Genetic and Molecular Changes of Human Lung Cancer Chapter 108 Epidemiology of Lung Cancer Chapter 109 Cigarette Smoking and Health Policy Chapter 110 The Solitary Pulmonary Nodule: A Systemic Approach Chapter 111 The Pathology of Non--Small Cell Lung Carcinoma Chapter 112 Non--Small Cell Lung Cancer--Clinical Aspects, Diagnosis, Staging, and Natural History Chapter 113 Part I: Treatment of Non--Small Cell Lung Cancer: Surgical Part II: Treatment of Non--Small Cell Lung Cancer: Chemotherapy Part III: Treatment of Non--Small Cell Lung Cancer: Radiation Therapy Chapter 114 Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History Chapter 115 Primary Lung Tumors Other Than Bronchogenic Carcinoma: Benign and Malignant Chapter 116 Extrapulmonary Syndromes Associated with Lung Tumors Chapter 117 Pulmonary Metastases Section 16 Lymphoproliferative Disorders Chapter 118 Lymphoproliferative and Hematologic Diseases Involving the Lung Part Sixteen INFECTIOUS DISEASES OF THE LUNGS Section 17 General Issues Chapter 119 Microbial Flora and Colonization of the Respiratory Tract Chapter 120 Pulmonary Clearance of Infectiou s Agents Chapter 121 Approach to the Patient with Pulmonary Infections Chapter 122 Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia Chapter 123 Local Therapy and Pharmacokinetics of Antibiotics in the Lungs Chapter 124 Vaccination for Pulmonary Infections Chapter 125 Microbial Virulence Factors in Pulmonary Infections Section 18 Pulmonary Infectious Syndromes Chapter 126 Infections of the Upper Respiratory Tract Chapter 127 Acute Bronchitis and Community-Acquired Pneumonia Chapter 128 Pneumonia in Childhood Chapter 129 Aspiration Disease and Anaerobic Infection Chapter 130 Empyema and Lung Abscess Chapter 131 Mediastinitis Chapter 132 Bronchiectasis Chapter 133 Systemic Infection, the Sepsis Syndrome, and the Lungs Section 19 Special Hosts and Opportunistic Infections Chapter 134 Introduction: Pulmonary Infection in Special Hosts Chapter 135 HIV Infection and Opportunistic Pulmonary Infections in AIDS Chapter 136 Pulmonary Infections in Neutropenia and Cancer Chapter 137 Respiratory Disease in Bone Marrow and Hematopoietic Stem Cell Transplantation Chapter 138 Pneumonia in the Organ Transplant Patient Chapter 139 Pulmonary Infections in Patients with Primary Immune Defects Chapter 140 Postoperative Pneumonia Chapter 141 Respiratory Infections in the Economically Disadvantaged Section 20 Specific Microorganisms Chapter 142 Pneumonias Caused by Gram-Positive Bacteria Chapter 143 Nosocomial Respiratory Tract Infections and Gram-Negative Pneumonia Chapter 144 Legionellosis Chapter 145 Mycoplasma, Chlamydia, and "Atypical Pneumonias" Chapter 146 Actinomycosis and Nocardiosis Chapter 147 Aspergillus Syndromes, Mucormycosis,and Pulmonary Candidiasis Chapter 148 Endemic Mycoses of North America: Histoplasmosis, Coccidioidomycosis, and Blastomycosis Chapter 149 Cryptococcal Infections Chapter 150 Pneumocystis Carinii Chapter 151 Viral Infections of the Lung and Respiratory Tract Chapter 152 The Lung in Human Immunodeficiency Virus Infection Chapter 153 Emerging Infectious Diseases and Hantavirus Pulmonary Syndromev Chapter 154 Poliovirus and Other Enterovirus Infections Chapter 155 Protozoan Infections of the Thorax Chapter 156 Helminthic Diseases of the Lungs Chapter 157 Zoonotic and Other Unusual Bacterial Pneumonias Section 21 Mycobacterial Infections Chapter 158 The Epidemiology, Transmission, and Prevention of Tuberculosis in the United States Chapter 159 The Microbiology of the Mycobacteria Chapter 160 Pathogenesis of Pulmonary Tuberculosis Chapter 161 Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations Chapter 162 Clinical Presentation and Treatment of Tuberculosis Chapter 163 Mycobacterial Infections and HIV Infection Chapter 164 Diseases due to Mycobacteria Other than Mycobacterium Tuberculosis Part Seventeen ACUTE RESPIRATORY FAILURE Section 22 Lung Failure Chapter 165 Respiratory Failure: An Overview Chapter 166 Acute Respiratory Distress Syndrome:Pathogenesis Chapter 167 Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcome Chapter 168 The Systemic Inflammatory Response Syndrome and the Multiple Organ Dysfunction Syndrome Chapter 169 Respiratory Distress Syndrome in Premature Newborn Infants Chapter 170 Acute Respiratory Failure in the Surgical Patient Section 23 Respiratory Pump Failure Chapter 171 Pump Failure: The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease Section 24 Management and Therapeutic Interventions Chapter 172 Oxygen Therapy and Pulmonary Oxygen Toxicity Chapter 173 Pulmonary Pharmacotherapy Chapter 174 Intubation and Upper Airway Management Chapter 175 Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure Chapter 176 Mechanical Ventilation: Conventional Modes and Settings Chapter 177 Mechanical Ventilation: Physiological Considerations and New Ventilatory Techniques Chapter 178 Nutrition in Acute Respiratory Failure Chapter 179 Treatment of Agitation and Distress in Mechanically Ventilated Patients Chapter 180 Decision Making in the Intensive Care Unit Chapter 181 Ethics in the Intensive Care Unit Chapter 182 Prevention and Control of Lung Disease APPENDIXES Appendix A Respiratory Questionnaire Appendix B Normal ValuesB-1 Appendix C Terms and Symbols in Respiratory PhysiologyC-1 INDEXI-1