Handbook of Experimental Pharmacology / Pharmacokinetics of Drugs

Drawing on the experiences of researchers in the areas of bioanalysis, pharmacokinetics and drug metabolism, this study presents up-to-date information on the application of these and related technologies to drug development and the clinical use of new drugs.

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This text draws together the experience of active researchers in the areas of bioanalysis, pharmacokinetics and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development and clinical use. The contents include descriptions of analytical methods, in vitro metabolism technology and membrane transport; a reappraisal of classical pharmacokinetic problems including disposition of chiral drugs, stereoselective metabolism, interethnic and environmental factors; and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and available personal computer pharmacokinetic software.