Drug Delivery

BINGHE WANG, PhD, is a professor and Georgia Research Alliance Eminent Scholar in Drug Discovery, and Georgia Cancer Coalition Distinguished Cancer Scientist in the Department of Chemistry, Georgia State University. He is Editor in Chief of Medicinal Research Reviews and a member of the Long-Range Planning Committee of the American Chemical Society, Division of Medicinal Chemistry. TERUNA SIAHAAN, PhD, is a professor in the Pharmaceutical Chemistry Department, University of Kansas, and a Fellow of the American Association of Pharmaceutical Scientists. RICHARD A. SOLTERO, PhD, President of PharmaDirections, Inc., is an executive- level scientist with extensive experience managing multisite and multinational pharmaceutical and biotechnology labs.

Preface. List of Contributors. 1. Factors that Impact the Developability of Drug Candidates-An Overview (Chao Han and Binghe Wang). 2. Chemical, Biochemical, and Physiological Barriers to Oral Drug Delivery (Teruna Siahaan). 3. Pathways for Drug Delivery to the Central Nervous System (Yan Zhang and Donald W. Miller). 4. Physiochemical Properties, Formulation and Drug Delivery (E. Munson). 5. Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery (William F. Elmquist). 6. Pre-Systemic and First-pass Metabolism (W. Griffith Humphreys). 7. Cell Culture Models for Drug Transport Studies (D. Nedra Karunaratne, Peter S. Silverstein, Veena Vasabdabi, Amber M. Young, Erik Rytting, Bradley Yops and Kenneth L. Audus). 8. Prodrug Approaches to Drug Delivery (Longqin Hu). 9. Receptor-Mediated Drug Delivery (Chirstopher P. Leamon and Philip S. Low). 10. Oral Protein and Peptide Drug Delivery (Rick Soltero). 11. Metabolic Activation and Drug Targeting (Xiangming Guan). 12. Ultrasound Mediated Drug Delivery (Ka-yun Ng' and Terry O. Matsunaga). 13. Polycationic Peptides and Proteins in Drug Delivery: Focus on Non-Classical Transport (Lisa A. Kueltzo and C. Russell Middaugh). 14. Gene Therapy and Gene Delivery (Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura). 15. Parenteral Formulations for Peptide and Protein Delivery, and Monoclone Antibody Drugs (John Bontempo). 16. Pulmonary Drug Delivery - Pharmaceutical Chemistry and Aerosol Technology (Anthony J. Hickey). 17. Antibody-Directed Drug Delivery (Herve Le Calvez, John Mountzouris, Kosi Gramatikoff and Fang Fang). 18. Efflux Transporters in Drug Excretion (Shuzhong Zhang and Marilyn E. Morris). 19. Liposome as Drug Delivery Vehicles (Guijun Wang). 20. Regulatory and IP Issues in Drug Delivery Research (Shihong Nicolaou). Index.