Toll-Like Receptors

Modelling of transmembrane domain and full length TLRs in membrane models.- Development of Optimal Virtual Screening Strategies to Identify Novel Toll-like Receptor Ligands using the DockBox Suite.- Use of Fluorescent Chemical Probes in the Study of Toll-like Receptors (TLRs) Trafficking.- Use of Fluorescent Chemical Probes in the Study of Toll-like Receptors (TLRs) Trafficking.- Endotoxin-tolerance mimicking to study TLR in promotion of tolerogenic DCs and Tr1 cells.- Flow cytometry analysis of IL-1 receptors and Toll like receptors on platelets and platelet-derived extracellular vesicles.- Methods to study TLRs in transplantation.- Determining endosomal Toll-like Receptors gene expression in NK cells after stimulation with specific agonists.- In vitro study of TLR4-NLRP3-inflammasome activation pathway in innate immune response.- Toll-like receptor polymorphisms and the risk of cancer: meta-analysis study.- Unrevealing the role of TLRs in the pathogenesis of autoimmune disease by using mouse model of diabetes.- In vitro and ex vivo methodologies for T cell trafficking through Blood Brain Barrier after TLR activation.- Delineating the role of Toll-like receptors in inflammatory bowel disease.- Analysis of differential TLR activation in a mouse model of multiple sclerosis.- Study of agonists of TLRs as vaccine adjuvants.- Activation of TLRs by opportunistic fungi in lung organoids.