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Percutaneous Penetration Enhancers

Buch | Hardcover
512 Seiten
1995
Crc Press Inc (Verlag)
978-0-8493-2605-9 (ISBN)
169,95 inkl. MwSt
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Up-to-date chemical and physical methods for the enhancement of percutaneous penetration are explored in this reference. Equipment is listed, typical drug candidates for the techniques are described and the success of such methods to date is discussed.
This book is a comprehensive reference on the methods available for the enhancement of percutaneous penetration. It examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed in this volume is unsurpassed anywhere in the literature. Scientists can find invaluable information in this single source on 95 percent of the enhancers being researched today!
Each well-illustrated chapter is written by the world's leading authorities in the field. Introductory chapters outline the concept of penetration enhancement from first principles and provide a comprehensive classification of different types of enhancers.Chapters covering chemical enhancers are clear, concise, and easy to understand, even for novice readers in this field. The latest techniques by which drugs can be forced physically through the skin are also covered in depth. Equipment is detailed, typical drug candidates for the techniques are described, and the success to date is provided.
Percutaneous Penetration Enhancers is the first book to present modern analytical techniques that have been used to assess penetration enhancement. The book also offers future perspectives for enhancers. New approaches and current limitations on knowledge and understanding of the topic are suggested. This timely source book is invaluable for clinical reference or for the design of scientific studies.

Smith; Eric Wane University of South Carolina, Columbia, South Carolina, USA,Maibach; Howard I. San Francisco, California, USA,

Percutaneous Penetration Enhancers: The Fundamentals, E.W. Smith and H.I. Maibach
Penetration Enhancer Classification, S. Chattaraj and R.B. Walker
Penetration Enhancement by Skin Hydration, R.C. Wester and H.I. Maibach
Effect of Hydration on Corticosteroid Absorption, J.M. Haigh and E.W. Smith
Use of Occluding Hydrocolloid Patches, D.A. Hollingsbee, R.J. White, and P.A.D. Edwardson
Alcohols, B. Berner and P. Liu
Propylene Glycol, B. Bendas and R. Neubert
Amines and Amides as Penetration Enhancers, B.B. Michniak
Alkyl N,N-Disubstituted-Amino Acetates, N. Büyüktimkin, S. Büyüktimkin, and J.H. Rytting
Decylmethylsulfoxide, E. Touitou and D. Chow
Dimethylsulfoxide, T.J. Franz
Penetration Enhancement using Azone, G. Allan
Human Stratum Corneum Barrier Impairment by N-Alkyl-Azacycloheptanones, J.A. Bouwstra and H.E. Boddé
Enhanced Percutaneous Absorption of Azone following Single and Multiple Doses to Human Volunteers, R.C. Wester and H.I. Maibach
Metabolism of the Penetration Enhancer Azone: In Vivo and In Vitro Studies in the Hamster, Rat, Monkey, and Man, J.W. Wiechers
Azone Analogues as Penetration Enhancers, B.B. Michniak
Interaction of Azone with Model Lipid Systems, G. Lee
Pyrrolidones as Penetration Enhancers, H. Sasaki, K. Nishida, and J. Nakamura
Drug-Polyvinylpyrrolidone Co-precipitates, O.I. Corrigan
Profile of Pirotiodecane (HPE-101): A New Potential Penetration Enhancer, T. Yano, Y. Shimozono, T. Manako, K. Fukuda, S. Yahiro, and K. Noda
Surfactants, S. Ruddy
Benzalkonium Chloride Polymers, T. Aoyagi and Y. Nagase
Silicone-Based Polymers, T. Aoyagi and Y. Nagase
Fatty Acids as Skin Permeation Enhancers, B.J. Aungst
Urea and Its Derivatives as Penetration Enhancers, A.C. Williams
Biodegradable Unsaturated Cyclic Ureas as Penetration Enhancers, O. Wong and J.H. Rytting
Terpenes as Penetration Enhancers, M. Hashida and F. Yamashita
Liposomes as Penetration Enhancers and Controlled Release Units, M.-H. Schmid and H.C. Korting
The Effect of Cyclodextrins on Percutaneous Transport of Drugs, T. Loftsson and N. Bodor
Triple Therapy: Multiple Dosing Enhances Hydrocortisone Absorption In Vivo in Man, R.C. Wester, J. Melendres, F. Logan, and H.I. Maibach
Iontophoresis, B.H. Sage
Ultrasound, E. Camel
Delipidization of the Cutaneous Permeability Barrier and Percutaneous Penetration, E. Menczel
Electroporation, M.R. Prausnitz, V.G. Bose, R. Langer, and J.C. Weaver
The Use of Ion Pairing to Facilitate the Percutaneous Absorption of Drugs, S. Matschiner, R. Neubert, and W. Wohlrab
Raman Spectroscopy, A.C. Williams and B.W. Barry
Electron Spin Resonance, D. Quan and H.I. Maibach
X-Ray Fluorescence, J.D. Robertson and M. Jay
Assessing Penetration Enhancers for Corticosteroids, E.W. Smith and J.M. Haigh
Fluorescence Spectroscopy, W. Abraham
Some New Approaches to Understanding and Facilitating Transdermal Drug Delivery, P.S. Magee
Future Perspectives for Penetration Enhancers, E.W. Smith and H.I. Maibach

Erscheint lt. Verlag 19.7.1995
Zusatzinfo 64 Tables, black and white
Verlagsort Bosa Roca
Sprache englisch
Maße 156 x 235 mm
Gewicht 862 g
Einbandart gebunden
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Dermatologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
ISBN-10 0-8493-2605-2 / 0849326052
ISBN-13 978-0-8493-2605-9 / 9780849326059
Zustand Neuware
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