Epigenetic Epidemiology

Karin B. Michels is Professor and Chair of the Department of Epidemiology at the Fielding School of Public Health at UCLA. She received a ScD in Epidemiology from Harvard University and a PhD in Biostatistics from Cambridge University, UK. She was Assistant and Associate Professor at Harvard Medical School until she joined UCLA in 2016. Dr. Michels is a co-founder of the field of epigenetic epidemiology. Her work focusses on the early life origins of cancer, the role of nutrition in maintaining health, and the impact of the environment on the epigenome and the microbiome. She has published more than 300 peer-reviewed publications. Her work has been supported by the National Institutes of Health, the American Cancer Society, the Department of Defense, the Komen Foundation, and the Breast Cancer Research Foundation.

Part 1: Basic Concepts and Methodologic Considerations.- The Human Epigenome.- Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology.- Laboratory Methods in Epigenetic Epidemiology.- Biostatistical Methods in Epigenetic Epidemiology.- Epigenome Reprogramming During Development.- The Role of Epigenetics in the Developmental Origins of Health and Disease.- Epigenetics and Assisted Reproductive Technology.- Imprinting Disorders.- The Utility of Twins for Epigenetic Analysis.- Age-Related Variation in DNA Methylation.- The Epigenetic Clock.- Influence of Environmental Factors on the Epigenome.- Part 2: Epigenetic Epidemiology of Complex Diseases.- Epigenetic Epidemiology of Cancer.- Epigenetic Epidemiology of Infectious Diseases.- Epigenetic Epidemiology of Inflammation and Rheumatoid Arthritis.- Asthma Epigenetics: Emergence of a New Paradigm?.- Epigenetic Epidemiology of Autism and other Neurodevelopmental Disorders.- Epigenetic Epidemiology of Psychiatric Disorders.- Epigenetic Epidemiology of Obesity and Type 2 Diabetes.- Epigenetics and Vascular Disease (Atherosclerosis).