Integrative Approaches in Environmental Health and Exposome Research

Elodie Giroux is Professor of philosophy of medicine at the philosophy department of Jean Moulin Lyon 3 University. Her research interests focus on the history of risk factor epidemiology, philosophy of epidemiology, causation in medicine and public health, health and disease concepts, and more recently precision medicine and integrative research in environmental health and exposomics. Francesca Merlin is Permanent research fellow in philosophy of biology at CNRS. She holds a PhD in Philosophy (University of Paris 1 Panthéon Sorbonne, 2009). Her research focuses on central concepts in biology such as chance and probability, inheritance and epigenetics, in particular in the context of evolutionary theory. She currently works on a new interdisciplinary research project on the concept of environment in the study of environmentally induced diseases, both in life sciences and in social sciences (EnviroBioSoc ANR project). Since 2018, she is President of the Société de Philosophie des Sciences (SPS). In 2019, she received the CNRS Bronze Medal. Yohan Fayet holds a PhD in Geography (Lyon 3 University, 2014) and is research project manager in Human and Social Sciences at the Léon Bérard Center in Lyon. He is interested in the analysis of spatial inequalities in health, through the multiple impact of physical, social and medical environments on health outcomes. He focuses on spatial inequalities in cancer and analyses potential challenges raised by innovations in oncology. He published a nationwide geographical classification in France to measure spatial inequalities in health (International Journal of Health Geographics, 2021) and works on potential actions to reduce it, such as the reference networks organization.

PART 1: Articulating the social and the biological.- Chapter 1: The turn towards 'the biosocial' in epigenetics. Ontological, epistemic and socio-political considerations.- Chapter 2: Socio-markers and the trace of information transmission.- Chapter 3: What's Wrong with the Biologization of Social Inequalities in Health? A history of social epidemiology and its moral economy of objectivity.- Part 2: Integration in environmental health and exposome research: epistemological issues.- Chapter 4: Which Integration for Health? Comparing Integrative Approaches for Epidemiology.- Chapter 5: A Critical Assessment of Exposures Integration in Exposome Research.- Chapter 6: From exposome to pathogenic niche. Looking for an operational account of the environment in health studies.- PART 3: The case of exposome research: practical and disciplinary issues.- Chapter 7: Place of integrative approaches in the study of spatial dimension of health outcomes.- Chapter 8: Exposome and the social sciences: the case of systemic diseases.- Chapter 9: The exposome research program and nutrition: the example of celiac disease.