Oxidative Stress and Aging

Introductory papers.- Oxidative stress, antioxidants, aging and disease.- Longevity determinant genes, cellular dysdifferentiation and oxidative stress.- Oxidative stress and cellular senescence.- Oxidative stress and apoptosis.- Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death.- Cellular aging and oxidative stress.- Cellular nitrogen oxide production: Its role in endogeneous mutation and carcinogenesis.- Vascular smooth muscle cell proliferation is controlled by d-?-tocopherol at the level of protein kinase C and of the transcription factor AP-1.- Genetic stability and damage: DNA repair.- DNA damage and epigenetic mechanisms of aging.- Formation of 8-hydroxyguanine in DNA by aging and oxidative stress.- Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress.- Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carcinogenesis.- DNA repair, oxidative stress and aging.- Genetics and lifespan.- Poly(ADP-ribose) polymerase: Correlation of enzyme activity with the life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation.- Antioxidant genes and other mechanisms involved in the extended longevity of Drosophila.- Proteins and lipid oxidation.- Novel approaches toward inhibition of the Maillard reaction in vivo: Search, isolation and characterization of prokaryotic enzymes which degrade glycated substrates.- Age-associated changes of oxidative modification and turnover of proteins.- Mitochondria.- Mitochondria, free radicals, neurodegeneration and aging.- Free radicals and muscle damage due to immobilization of old animals: Effect of growth hormone.- PCR analysis of mitochondrial DNA from normal and transgenic glutathione peroxidase mice.- Aging related diseases and cancer.- Free radicals in the pathogenesis of diabetes and its complications.- Oxidative stress and its relationship to carcinogen activation.- The chemoprevention of cancer by dietary carotenoids: Studies in mouse and human cells.- Accumulation of ubiquitinated proteins in aging mouse brains.- Protective action of Bio-normalizer against oxidative stress and brain disorders.- Islet redox state, calcium uptake and insulin secretion: Effects of old age and oxidative stress.- Free radical scavenger properties of EGB 761 on functional disorders induced by experimental diabetic retinopathy.- Aging related diseases: Neurodegeneration.- Oxidative stress in neurobiology: An important role for iron.- Parkinson’s disease, dopamine and free radicals.- Oxidative stress and brain damage as the pathogenesis of epilepsy.- Senile neurodegeneration: Pathogenic role of microglia-derived free radicals.- Nutrition.- Modulation of oxidative stress as a means of life-prolonging action of dietary restriction.- Dietary vitamin E in oxidative stress and aging.- Tea and its components as powerful antioxidants.- Protective role of dietary antioxidants in oxidative stress.- Nitric oxide.- Nitrone spin-traps release nitric oxide reaction with reactive oxygen species: Possible mechanism of biological activity.- Age-related changes in nitric oxide content and nitric oxide synthase activity in senescence-accelerated mouse (SAMP8) brain.