Essentials of Pharmatoxicology in Drug Research, Volume 1

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

1. Understanding Pharmacotoxicology
2. Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development
3. Omics in Mechanistic and Predictive Toxicology
4. Role of Micro RNAs in Toxicology
5. Exosomes as Mediators of Chemical-Induced Toxicity
6. Types of Cellular Responses to Chemical Toxicants
7. Tissue Repair as A Key Determinant in Toxicant-Induced Injury
8. Role Of “Toxicant-Induced Loss of Tolerance” in the Emergence of Disease
9. Computer-Aided Technologies in Drug Discovery and Toxicity Prediction
10. Adverse Outcome Pathway for Chemical Toxicity
11. Toxicokinetics and Organ-Specific Toxicity
12. Dose Selection for Toxicity Studies
13. Tissue-Based Models as A Replacement for Animal Models in Toxicity Testing
14. Medication Error and its Toxicity Connection
15. Idiosyncratic Toxicity
16. Toxicological Risk Assessment
17. Clinical Detoxification of the Body
18. Principles of Management of Acute Poisoning
19. Predicting Toxicity and Modes of Toxic Action from Chemical Structure
20. Toxicity Labels
21. Toxic Potential Indicator
22. Aquatic Toxicology
23. Concept of Pharmacotherapy and Managed Care in Clinical Interventions
24. Psychopharmacology in Late Life: Key Challenges and Opportunities
25. Regulatory Agencies for Toxicity Studies
26. Key Challenges for Toxicologists in the 21st Century