Forensic DNA Evidence Interpretation

Biological Basis for DNA Evidence, Peter Gill and John Buckleton
Historical and Background Biology
Understanding PCR Profiles
A Framework for Interpreting Evidence, John Buckleton
The Frequentist Approach
The Logical Approach
The Full Bayesian Approach
A Possible Solution
A Comparison of the Different Approaches
Population Genetic Models, John Buckleton
Product Rule
Simulation Testing
Discussion of the Product Rule and the Subpopulation Model
A Complex Case Example - DNA Evidence and Orethral James Simpson
Relatedness, John Buckleton and Christopher Triggs
Conditional Probabilities
Joint Probabilities
The Unifying Formula
The Effect of Linkage
Validating Databases, John Buckleton
Which Is the Relevant Population?
Population Databases
Validating the Population Genetic Model
Estimating Q
Descriptive Statistics for Databases
Sampling Effects, John Buckleton and James Curran
Bounds and a Level
Methods for Assessing Sampling Uncertainty
Minimum Allele Probabilities
Discussion of the Appropriateness of Sampling Uncertainty Estimates
Mixtures, Tim Clayton and John Buckleton
Frequentist Approaches
Bayesian Approaches
Statistical Evaluation of Mixtures
Low Copy Number, John Buckleton and Peter Gill
Changes in LCN Profile Morphology
The Interpretation of LCN Profiles
Non-autosomal Forensic Markers, Simon Walsh, SallyAnn Harbison, and John Buckleton
Forensic Mitochondrial DNA Typing
Forensic Y Chromosome Analysis
Forensic X Chromosome Analysis
A Famous Case Example - The Romanovs
Parentage Testing, John Buckleton, Tim Clayton, and Chris Triggs
Evaluation Of Evidence
Paternity Trios: Mother, Child and Alleged Father
Non-autosomal DNA
Use of the Sub-Population Model of Balding and Nichols to Evaluate the Paternity Index
Relatedness in Paternity Cases
Multiple Children
Inconsistencies in the Mendelian Pattern
'Exclusions'
Paternity Trios: Mother, Child and Alleged Father Considering the Possibility of Silent (Null) Alleles
Disaster Victim Identification, Identification of Missing Persons, and Immigration Cases, John Buckleton, Chris Triggs, and Tim Clayton
Mitochondrial or Nuclear DNA?
Human Remains - Obtaining a Profile from Bodily Remains
Extraction of DNA from Bone, Tooth, Hair and Nail
Complicating Factors
DNA Intelligence Databases, Simon Walsh and John Buckleton
A Brief History
Functional Aspects
Legislation
Aspects of Forensic Significance
Social and ethical considerations
Interpretation Issues Associated with DNA Databases