Ovulation Induction: Basic Science and Clinical Advances

Part 1 Hypothalamic-pituitary control of ovulation: some modulation of hypothalamic neuronal activity in the rhesus monkey, E. Knobil; pituitary translation of the pulsatile GnRH message, J.C. Marshall et al; ovulation and LH-regulated genes, J.S. Richards; follicular development - the role of LH, D.A. Magoffin et al; gonadotropic control of folliculogenesis - the threshold theory, A.J. Zeleznik. Part 2 Nongonadotropic regulation of ovarian function: nongonadotropic regulation of ovarian function - roles of follicular sex steroids, S.G. Hillier; the effects of exogenous recombinant human activin A on pituitary and ovarian hormone secretion and ovarian folliculogenesis in female rats and monkeys, T.K. Woodruff et al; nongonadotropic regulation of ovarian function - insulin, J.F. Cara, growth hormone and IGFs, G.F. Erickson, interleukin-1, E.Y. Adashi. Part 3 Pathophysiology of anovulation: LH-dependent polycystic ovary syndrome, S.L. Berga; role of obesity and insulin in the development of anovulation, J.E. Nestler; hypergonadotropic amenorrhea, R.W. Rebar and M.I. Cedars. Part 4 Ovulation induction with gonadotropins: purified FSH - characteristics and applications, C. Flamigni et al; induction of ovulation with gonadotrophins - hMG versus purified FSH, D.T. Baird and C.M. Howles; low-dose gonadotropin regimens for induction of ovulation, S. Franks et al; step-down follicle-stimulating hormone regimens in polycystic ovary syndrome, B.C.J.M. Fauser; use of FSH threshold administration in polycystic ovarian disease, J. Schoemaker et al; endometrial receptivity in controlled ovarian hyperstimulation (COH) - the hormonal factor, D. de Ziegler and R. Fanchin. Part 5 Recombinant gonadotropins - basic aspects: structure-function studies of gonadotropins using site-directed mutagenesis and gene transfer - design of a long-acting gonadotropin agonist, I. Boime et al; control of gonadotropin binding specificity, R.K. Campbell; new recombinant hCG analogs with potent FSH activity in vivo, Y. Wang et al. Part 6 Recombinant gonadotropins - clinical aspects: pharmacokinetics of natural/recombinant FSH (follitropin) and some analogs, M.R. Sairam and K. Sebok; biological action of recombinant human FSH (Puregon(R)) during induction of multiple follicular growth, B. Mannaerts et al; potential clinical applications of recombinant FSH, H.J.T. Coelingh Bennink et al; ovulation induction with recombinant human follicle stimulating hormone and luteinizing hormone, E. Loumaye et al. Part 7 Ovulation induction with pulsatile GnRH: use of GnRH and its analogs in the treatment of ovulatory disorders - an overview, M. Filicori; appropriate regimens of pulsatile gonadotropin-releasing hormone (GnRH) administration, G.B. Wilshire and N. Santoro; pulsatile GnRH in hypogonadotropic hypogonadism, K.A. Martin et al; pulsatile GnRH in multifollicular and polycystic ovary patients, H.S. Jacobs. (Part contents).