Stem Cell in Medicine

Prof. Higuchi is a distinguished Professor in National Central University, a guest researcher in RIKEN (Japan) and National Research Center for Child Health and Development (Tokyo), and a visiting professor in King Saud University (Saudi Arabia) and Wenzhou Medical University (China). He received his Ph.D. in Tokyo Institute of Technology in 1985. He was a Professor in Seikei University (Tokyo) from 1993 to 2007. He received Sofue Memorial Award from Society of Fiber Science, Japan in 1994, Seikei Academic Award from Seikei Alumni Association in 2003, and Nanotechnology Outstanding Contribution Award, National Science Council, Taiwan in 2013, Future Tech Breakthrough Award in 2019, Ministry of Science and Technology, Taiwan. He also received Outstanding Scientific Award, Tissue Engineering and Regenerative Medicine International Society, Asia Pacific region (TERMIS-AP) in 2021. He is a fellow of Royal Society of Chemistry (RSC, England), a fellow of Taiwan Chemical Engineering Society, and a fellow of American Institute for Medical & Biological Engineering (AIMBE, USA). He is interested in the development of materials for stem cell culture and differentiation. He established purification method of hematopoietic stem cells and mesenchymal stem cells from umbilical cord blood and adipose tissue, respectively by filtration method through polymeric porous membranes. He is also developing biomaterials for stem cell culture and differentiation. He emphasized the important function of cell culture biomaterials, which guide differentiation fate of human pluripotent stem cells and mesenchymal stem cells into specific lineage of the cells. He developed ECM-derived peptide-immobilized hydrogels having adjustable elasticity for culture and differentiation of human pluripotent stem cells. He is now developing universal (hypoimmunogenic) human pluripotent stem cells on specific ECM-coated surface. He is an advisory board of Journal of Materials Chemistry B (RSC), an Editor of Open Physics, Editorial Board of Laboratory Investigation, Editorial Board of Tissue Engineering and Regenerative Medicine, and Associate Editor of IET Nanobiotechnology. Dr Yinghong Zhou is a Senior Research Fellow leading the Translational ImmunoEngineering for Regenerative Dentistry research team at the School of Dentistry, University of Queensland. Dr Zhou obtained her PhD in Biomedical Engineering from the Queensland University of Technology (QUT) in 2013. Dr Zhou seeks to understand the mechanisms for bone repair and regeneration, with a particular interest in stem cell-based therapy and biomaterial application. She has been awarded a prestigious NHMRC Early Career Fellowship (2016-2020) to investigate cell signalling cues involved in periodontal tissue regeneration, an Endeavour Research Fellowship (2017) for a collaborative project on cell transformation at Texas A&M University College of Dentistry, and a BridgeTech Program Fellowship (2021) to advance research towards commercialisation. Dr Zhou was appointed as the Coordinator of the Australia–China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM) in 2013, then Deputy Director in 2016 and has worked in the role since. Prof. Shih-Hwa Chiou is a physician-scientist, the Director of Department of Medical Research in Taipei Veterans General Hospital, and distinguished Chair Professor in the Institute of Pharmacology and the Institute of Clinical Medicine & Genomic Center, of National Yang-Ming University in Taiwan. He had been trained in the Department of Molecular Biochemistry of The Boston Children Hospital of Harvard Medical School and the Department of Molecular Biochemistry of The Scripps Research Institute in USA as a visiting Researcher. He won the Young Investigator Award, in the Annual Meeting of Society of Molecular Imaging (Germany) and the Achievement Award of the Society of Asia-Pacific Academy of Ophthalmology (Australia). He was invited to be a Chairman & Keynote speaker at the Cancer Stem Cell Section in 69th Annual Meeting, Japan Cancer Association (JCA) in Japan. Currently, he devotes in using iPSC-derived 3D organoid as disease models for researches in genetic-mutation diseases, drug screening, and nanomedicine-based genomic editing technology in personalized medicine.

Preface

Akon Higuchi, Yinghong Zhou and Shih-Hwa Chiou



Introduction to stem cells
Zeyu Tian, Tao Yu, Jun Liu, Ting Wang, and Akon Higuchi

Engineered adult stem cells: current clinical trials status of disease treatment
Pingping Han, Corey Stephan Moran, Chun Liu, Rebecca Griffiths, Yinghong Zhou, and

Sašo Ivanovski

Xeno-free culture and proliferation of hPSCs on 2D biomaterials
Ting Wang, Tao Yu, Chang-Yen Tsai, Zhao-Yu Hong, Wen-Hui Chao, Yi-Shuo Su, Suresh Kumar Subbiah, Remya Rajan Renuka, Shih-Tien Hsu, Gwo-Jang Wu, and Akon Higuchi

Stem cell culture and differentiation in 3-D scaffolds
Yasuhiko Tabata, Idaszek Joanna, and Akon Higuchi

Current trends and promising clinical utility of IPSC-derived MSC (iMSC)
Shih-Hwa Chiou, Alan Han Kiat Ong , Shih-Jie Chou, Ahmed Faris Aldoghachi, Jit Kai Loh, Nalini Devi Verusingam,

Yi-Ping Yang, and Yueh Chien

Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells
Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Hidenori Nonaka, Masashi Toyoda, Akihide Kamiya, Tohru Kiyono, Tohru Kimura, Mureo Kasahara, and Akihiro Umezawa

Cardiac cell sheet engineering for regenerative medicine and tissue modeling
Katsuhisa Matsuura and Tatsuya Shimizu

Mesenchymal stem cells in osteoarthritis: The need for translation into clinical therapy
Feng Gao, Xinzhan Mao, and Xiaoxin Wu

hPSC-derived RPE transplantation for the treatment of macular degeneration
Qian Liu, Jun Liu, and Akon Higuchi

Universal and hypoimmunogenic pluripotent stem cells for clinical usage
Tzu-Cheng Sung, Kailibinuer Maitiruze, Jiandong Pan,

Jian Gong, Yongheng Bai, Xiaodong Pan, and Akon Higuchi

Clinical Usage of Dental Stem Cells and Their Derived Extracellular Vesicles
Yinghong Zhou, Tian Xu, Cong Wang, Pingping Han, and Sašo Ivanovski

Vascularization of cutaneous wounds by stem cells
Motaharesadat Hosseini and Abbas Shafiee

Application of IPSC and Müller glia derivatives in retinal degenerative diseases
Guoge Han, Pinghui Wei, and Quanhong Han

Pluripotent Stem Cells as a Therapy for Type 1 Diabetes
Bernard E. Tuch, Iris S. Cheng, Hoang Phuc Dang, Hui Chen, and Tim R. Dargaville

Stem cell challenges and opportunities

Kenta Ite, Masashi Toyoda, Saeko Akiyama, Shin Enosawa, Saeko Yoshioka,

Takaaki Yukitake, Mayu Yamazaki-Inoue, Kuniko Tatsumi, Hidenori Akutsu, Hiroshi Nishina, Toru Kimura, Naoko Otani, Atsuko Nakazawa, Akinari Fukuda, Mureo Kasahara, and Akihiro Umezawa