Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies

I. Selected Topics: A. Introduction.- 1. Osteosarcoma at the end of the 20th century/Tumor biology.- B. General.- 2. Retroviruses and oncogenes associated with osteosarcomas.- 3. In vivo 31-phosphorus nuclear magnetic resonanc spectroscpy of osteosarcoma.- 4. Perioperative blood transfusions and survival in osteosarcoma.- 5. Adjuvant interferon treatment in human osteosarcoma.- 6. Difference of osteosarcoma between Southwest England and the Kanto area of Japan in relation to age, sex and localization.- 7. Psychological effects of amputation in osteosarcoma.- 8. Late effects of therapy in survivors of childhood and adolescent osteosarcoma.- C. Pharmacology.- 9. An opinion supporting the role of high-dose methotrexate in the treatment of osteosarcoma.- 10. Doxorubicin: Role in the treatment of osteosarcoma.- 11. Pediatric osteosarcoma: Treatment of the primary tumor with intraarterial cis-Diamminedichloroplatinum-II (CDP) Advantages, disadvantages and controversial issues.- 12. Intraarterial chemotherapy for osteosarcoma: Does the result really justify the effort.- 13. Thermal chemosensitization of DDP in normal and resistant cells.- 14. Liposome-encapsulated muramyl tripeptide: A new biologic response modifier for the treatment of osteosarcoma.- D. Pathology.- 15. Pathological diagnosis of osteosarcoma: The validity of the subclassification and some new diagnostic approaches using immunohistochemistry.- 16. Histologic subclassification of osteosarcoma: Differential diagnostic problems and immunohistochemical aspects.- 17. Small cell osteosarcoma.- 18. Current status of DNA cytometry in osteosarcoma.- 19. Osteosarcomatosis and metastatic osteosarcoma.- E. Radiotherapy.- 20. Experience of the EORTC Radiotherapy/Chemotherapy Group and in osteosarcoma trials.- 21. Intraoperative radiation therapy for osteosarcoma.- F. Surgery.- 22. Surgery of osteosarcoma of the extremities: Indications and Complications in the recent experience at the Instituto Ortopedico Rizzoli.- 23. Limb sparing for skeletally immature patients with osteosarcoma: The expandable Prosthesis.- 24. A modular endoprosthetic system, non-invasively extendable, for young patients with osteosarcoma.- 25. A critique of techniques for reconstruction after internal hemipelvectomy for osteosarcoma.- 26. Diffusion of methotrexate from surgical acrylic cement.- 27. Hyperthermic isolated prefusion using Cisplatin for the treatment of the extremities.- 28. Hyperthermic isolation limb perfusion (HILP) in the management of extremity melanoma and sarcoma with particular reference to the dosage, pharmacokinetics and toxicity of Cisplatin.- 29. Effect of isolated limb prefusion with Cisplatin (CDDP) on canine osteosarcoma.- 30. Salvage surgery for childhood osteosarcoma.- II. CO-Operative Groups And Institutional Reports: A. Co-operative Groups.- 31. The Multiinstitutional Osteosarcoma Study: An update..- 32. Treatment of osteosarcoma: Experience of the Cooperative Osteosarcoma Study Group (COSS).- 33. The European Osteosarcoma Intergroup (E.O.I.) Studies 1980–1991.- 34. The Children’s Cancer Study Group (CCSG) Studies.- 35. An update of Scandinavian studies of osteosarcoma.- B. Institutional Reports.- 36. Neoadjuvant chemotherapy for non metastatic osteosarcoma of the extremities: The recent experience at the Rizzoli Institute.- 37. Osteosarcoma of the extremities: Chemotherapy experience at Memorial Sloan-Kettering.- 38. Osteosarcoma studies at St. Jude Children’s Research Hospital from 1968 through 1990.- 39. A monocentric therapy study: An approach to optimize the results of thetreatment of osteosarcoma by protocols based upon HD MTX, associated with systematic conservative surgery.- 40. The Mayo Clinic studies.- 41. Neoadjuvant Chemotherapy for Patients with osteosarcoma: University of Flordia studies.- 42. Chemotherapy in osteogenic sarcoma: The experience of the Pediatric Department of the Gustave Roussy Institute.- 43. Results of therapy in osteosarcoma: Experience in children hospitals in Buenos Aires.- 44. Osteosarcoma: Experience with the Rosen T10 protocol at RCH, Melbourne.- 45. Osteosarcoma of the limb: An institutional report of 10 years experience with neoadjuvant chemotherapy and delayed surgery.- 46. Osteosarcoma: Experience of the Tata Memorial Hospital, Bombay, India.- 47. Update of osteosarcoma in Ramathibodi, Thailand.- III. Summaries, Critiques and Editorial Comments.- 48. Commentary on pathology.- 49. Is there a rational role for radiotherapy in the treatment of osteosarcoma? A radiotherapist’s point of view.- 50. Commentary on the use of presurgical chemotherapy.- 51. Critique on the use of presurgical chemotherapy.