Features and Management of Acute and Chronic Neuro-Covid

Marco Cascella, MD, currently works at the Department of Supportive Care at the National Cancer Institute, Fondazione “G. Pascale” – IRCCS, Naples, Italy, where he has responsibility for research in anesthesia and pain medicine. He is also an annual Professor of Physiology on the Degree Course in Biomedical Laboratory Techniques at the Faculty of Medicine, University “Federico II”, Naples. He is an active member of the scientific board on cancer pain and palliative care of the Italian Society of Anesthesia (SIAARTI). Dr. Cascella is an active researcher with special interests in the mechanisms of general anesthesia, anesthesia-related neurocognitive phenomena, antibiotic therapy in critically ill patients, and pain medicine. His work also includes preclinical investigations with a particular focus on nutraceuticals as promising therapeutics in neurodegenerative disease as well as on the role of opioids in the processes of cancerogenesis. He is head and co-investigator of different research projects and serves as Editor for research projects sponsored by the Italian Ministry of Health and as a member of scientific boards for the drafting and revision of guidelines in anesthesia and pain medicine. He is scientific reviewer and coordinator for the protocols implemented by the Multidisciplinary Emergency Unit for COVID-19 of the Campania Region (Italy). Dr. Cascella has been chairmen and speaker at numerous conferences and conventions. He has published over 150 scientific publications, including peer-reviewed manuscripts, books, and book chapters. Elvio De Blasio, MD, has worked at the Multidisciplinary Emergency Unit for COVID-19 of the Campania Region (Italy), Italy as scientific manager during the SARS-CoV-2 pandemic. Dr. De Blasio graduated in Medicine and Surgery with honors, in 1982, at the University “Vanvitelli” of Naples and then undertook postgraduate studies in Anesthesia and Intensive Care, gaining his doctorate in 1985. He received the European Diploma in Intensive Care Medicine (European Society of Intensive Care Medicine) in 1994. He is past head of the Anesthesia and Intensive Care Division and Director of the Emergency Department of the San Pio Hospital, Benevento, Italy. He was Director of Advanced Life Support and Pre-Hospital Trauma Care courses (Italian Resuscitation Council) and is co-Director of Advanced Trauma Life Support courses (American College of Surgeons). His research interests are critical care medicine, trauma medicine, sepsis, and mechanical ventilation in ICU. Dr. De Blasio has been chairmen and speaker at numerous conferences and conventions and has published scientific publications, including textbooks on critical care, and peer-reviewed manuscripts.

Introduction.- Part I. Pathophysiology of COVID-19-associated neurotoxicity.- An update on preclinical findings.- Ongoing clinical investigations.- Perspectives.- Part II. Clinical manifestations of acute neurotoxicity.- Clinical features.- CNS complications.- PNS complications.- Diagnosis.-Management.- Perspectives.- Part III. Neurological and psychiatric sequelae in COVID-19 survivors.-Clinical features.- Neurological late complications.- psychological and psychiatric sequelae.-Diagnosis.- Tools.- The role of imaging.- Preventive strategies.- Social and economic impact.-Multidisciplinary management.- Perspectives.