Hemostasis Management of the Pediatric Surgical Patient

Biography: Dr. Guzzetta is Professor of Anesthesiology and Pediatrics at Emory University School of Medicine and Children’s Healthcare of Atlanta in Atlanta, Georgia, USA. She has been a practicing pediatric cardiac anesthesiologist since 1994. In addition to a busy clinical practice, she has performed extensive research focused on hemostasis in children, understanding the developmental changes in the hemostatic system of children and how these changes impact the clinical treatment of bleeding during major surgery. As a pediatric cardiac anesthesiologist, Dr. Guzzetta is particularly skilled in the hemostatic response to cardiopulmonary bypass (CPB) in neonates, infants and young children. Her research involves primarily translational or clinical investigations that focus on 1) understanding the maturational differences between the pediatric and adult hemostatic systems, 2) anticoagulation management of pediatric cardiac surgical patients undergoing CPB, 3) identification of factors associated with an increased risk of bleeding in children undergoing major surgery and 4) efforts to reduce bleeding and transfusion requirements including the use of novel pro-coagulant therapies. She has published numerous research articles, review articles and written book chapters on these important topics. Her expertise in the hemostatic system of children, her work with children presenting for major surgical procedures and her knowledge of pediatric blood conservation will help ensure the ultimate success of the proposed book. Dr. Faraoni is a Professor of Anesthesia at Baylor College of Medicine, and a practicing pediatric cardiac anesthesiologist at Texas Children’s Hospital in Houston, Texas. Originally from Belgium, Dr. Faraoni worked as a pediatric cardiac anesthesiologist and a clinical researcher at Queen Fabiola Children’s University Hospital and the Free University of Brussels, Boston Children’s Hospital and Harvard Medical School, and the Hospital for Sick Children and the University of Toronto. Dr. Faraoni is involved in both clinical management and research initiatives examining blood conservation in pediatric patients undergoing major surgical procedures. His expertise in pediatric blood management poised him as the lead author in the development of 2019 NATA (Network for the Advance of Transfusion Alternatives) Guidelines for “Patient Blood Management for Neonates and Children Undergoing Cardiac Surgery”. He has authored numerous research articles, review articles, and book chapters on blood management for children undergoing major surgeries. Cassandra Josephson, M.D. is Professor of Oncology and Pediatrics at Johns Hopkins University School of Medicine. She is currently the Director of the Cancer and Blood Disorders Institute, Clinical Division Director for Hematology/Oncology, Medical Director of Blood Banking/Transfusion Medicine and Apheresis, at the Johns Hopkins All Children’s Hospital in St. Petersburg, Florida. She hails from Florida where she attended the USF Health Morsani College of Medicine prior to training at the University of Colorado for her pediatric residency. Subsequently, she trained at Emory University College of Medicine for Pediatric Hematology/Oncology and Blood Banking/Transfusion Medicine training. She spent the following 20 years at Emory University prior to joining Johns Hopkins School of Medicine in 2022. Dr. Josephson’s research career focuses on pediatric transfusion medicine and, more specifically, transfusion therapy in neonates, sickle cell anemia, thalassemia, and massive transfusion in children with hemorrhage. She currently and previously garnered grants from National Institutes of Health, CDC, industry and private foundations where she is or has been the Principal Investigator. Dr. Josephson is actively involved in teaching medical students, residency, and fellowship trainees in pediatrics, pathology, anesthesia, and multiple surgical specialties. She has authored or co-authored high impact publications in peer-reviewed journals, in addition to numerous review articles and book chapters. She is one of the Co-Chairs for the REDS IV-Pediatrics Program evaluating Recipient Epidemiology and Donor Evaluation of Blood Products and Transfusion in the US and Brazil focused on Children. She also services as an Associate Editor for Transfusion, the journal of the Association for the Advancement of Blood & Biotherapies (AABB).

Section 1: Basics of Hemostasis1. Mechanisms of Hemostasis 2. Developmental Hemostasis 3. Measuring and Monitoring of Hemostasis

Section 2: Disorders of Hemostasis in Children4. Congenital Bleeding and Thrombotic Disorders 5. Acquired Disorders of Hemostasis

Section 3: Blood Bank Management for Pediatric Patients6. Pediatric Blood Banking: Blood Components, Derivatives, Modifications, and Pre-Transfusion Testing 7. Consent and an Approach to the Management of Acute and Chronic Transfusion Reactions

Section 4: Perioperative Pediatric Blood Management8. Guidelines and Administration of Patient Blood Management Programs 9. Preoperative Optimization 10. Blood Conservation Strategies and Alternatives to Blood Products

Section 5: Hemostatic Management for Specific Surgical Procedures11. Major Spine and Orthopedic Surgery 12. Neurosurgical Prcedures 13. Cardiac Surgery and Cardiopulmonary Bypass (CPB) 14. Extracorporeal Membrane Oxygenation (ECMO) and Other Extracorporeal Devices 15. Major Abdominal Surgery 16. Pediatric Trauma 17. Biomaterials and Other Adjuncts for Pediatric Hemostasis

Section 6: Postoperative Challenges in Hemostasis18. Bleeding Management in the ICU 19. Postoperative Thrombosis and Prophylaxis