Oral Anticoagulants

Buch | Hardcover

288 Seiten

1996
Hodder Arnold (Verlag)
978-0-340-55266-7 (ISBN)

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With contributions from a number of experts in the field, this study provides detailed coverage on all aspects of oral anticoagulants. Among the topics covered are clinical pharmacodynamics, methods of individualizing dosing regiments, and laboratory monitoring.

Warfarin and related drugs have been used for over half a century in prevention and treatment of thrombotic disorders. Only recently however has their clinical role been firmly established by randomised studies and their benefit/risk ratio improved by lower dose therapy with improvements in laboratory monitoring.

'Oral Anticoagulants' is the first comprehensive, practical survey of the subject available. An international team of recognised experts provide detailed coverage on the mode of action; clinical pharmodynamics; magnitude and sources of variability in individuals response to oral anticoagulant; methods of individualising dosing regimens; laboratory monitoring; and comparison between the different currently prescribed oral anticoagulants.

Preface
The history of the development of oral anticoagulant drugs
Structure and mechanisms of activation of vitamin K antagonists
Pharmacokinetics and drug interactions with Warfarin
Laboratory monitoring of anticoagulants
Proteins induced by vitamin K absence (PIVKA's)
the effect of coumarins circulating clotting factors
Effects of vitamin K and oral anticoagulants on human bone metabolism
Human recombinant tissue factor. Development and initial studies in monitoring Warfarin
The effects of oral anticoagulants on molecular markers of thrombosis
Oral anticoagulants in the prevention and treatment of venous thromboembolism
Atrial fibrillation and oral anticoagulants
Oral anticoagulants in the secondary and primary prevention of myocardial infarction and coronary death
Valvular heart disease and heart valve prosthesis
Oral anticoagulants for prevention of stroke and cerebral embolism
Practical dosing considerations with Warfarin and optimal therapeutic range
Use of anticoagulants in pregnancy
Hemorrhagic complications or oral anticoagulant therapy
Oral anticoagulation therapy in paediatric patients
Warfarin in the treatment of cancer
Oral anticoagulants in the elderly
Indications and results with combined Warfarin and antiplatelet drugs
Anticoagulation in cardiomyopathy
Rebound hypercoagulability after discontinuation of oral anticoagulants
Index

Erscheint lt. Verlag	2.8.1996
Verlagsort	London
Sprache	englisch
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	0-340-55266-2 / 0340552662
ISBN-13	978-0-340-55266-7 / 9780340552667
Zustand	Neuware