Cancer Consult: Expertise in Clinical Practice, Volume 1

Syed A. Abutalib, MD, is Co-Director of Hematology and Stem Cell Transplantation and Clinical Director of NMDP® Apheresis Center at the Midwest Branch of Cancer Treatment Centers of America, (CTCA), Part of City of Hope. Maurie Markman, MD, is President of Medicine & Science, Cancer Treatment Centers of America, Part of City of Hope. Al B. Benson III, M.D FACP FASCO, is a Professor of Medicine in the Division of Hematology/Oncology at Northwestern University’s Feinberg School of Medicine in Chicago, Illinois, and the Associate Director for Cooperative Groups at the Robert H. Lurie Comprehensive Cancer Center. Hope S. Rugo, MD, FASCO, is Director of Breast Oncology and Clinical Trials Education and a Professor of Medicine at the University of California San Francisco Comprehensive Cancer Center.

Editors Volume 1 xi

Volume 2: Neoplastic Hematology & Cellular Therapy

Editors xii

Editor's Biography xiii

Preface xv

Acknowledgment xvii

Part 1 Central Nervous System 1

1 Central Nervous System Tumors 3
Mark R. Gilbert and Edina Komlodi-Pasztor

Part 2 Head and Neck and Thoracic Cancers 13

2 Localized Head and Neck Cancer 15
Emrullah Yilmaz and Jessica L. Geiger

3 Recurrent and Metastatic Head and Neck Cancer 31
Chloe Weidenbaum and Mike Gibson

4 Thyroid Cancers 39
Kartik Sehgal and Jochen H. Lorch

5 Non-Small Cell Lung Cancer: Screening, Staging, and Stage I 51
Ryan D. Gentzler and Linda W. Martin

6 Non-Small Cell Lung Cancer: Stages II and III 63
Gregory Peter Kalemkerian, Kamya Sankar, and Angel Qin

7 Recurrent and Metastatic Non-Small Cell Lung Cancer 79
Julia Judd, J. Nicholas Bodor, and Hossein Borghaei

8 Small Cell Lung Cancer 97
Jyoti D. Patel and Husam Hafzah

9 Mesothelioma 105
Harvey I. Pass, David Chen, and Jack Donaghue

Part 3 Breast Cancer 115

10 DCIS and LCIS 117
Amanda Nash, Rita Mukhtar, and Shelley Hwang

11 Early-Stage ER/PR –Positive, HER2-Negative Breast Cancer 129
William J. Gradishar

12 ER/PR-Positive, HER2-Negative Metastatic Breast Cancer 139
Sara Nunnery, Laura Kennedy, and Sonya Reid

13 Early-Stage HER2-Positive Breast Cancer 151
Erin Roesch and Jame Abraham

14 HER2-Positive Metastatic Breast Cancer 163
Reshma L. Mahtani, Naomi G. Dempsey, and Ana Sandoval

15 Early-Stage Triple-Negative Breast Cancer 179
Tiffany A. Traina, Carlos dos Anjos, and Elaine Walsh

16 Triple-Negative Metastatic Breast Cancer 191
Azadeh Nasrazadani, Juan Gomez, and Adam Brufsky

17 Inflammatory Breast Cancer – A Distinct Entity 201
Massimo Cristofanilli and Elena Vagia

18 Male Breast Cancer 213
Laura A. Huppert, Ozge Gumusay, Shreya Desai, and Hope S. Rugo

19 Breast Cancer in Pregnancy and Fertility Preservation 225
Fedro A. Peccatori, Hatem Azim, and Matteo Lambertini

Part 4 Gastrointestinal Cancers 233

20 Early-Stage Gastroesophageal Cancer and Precursor Lesions 235
Yixing Jiang and Aaron Ciner

21 Metastatic Esophagogastric Cancer 249
Geoffrey Y. Ku and David H. Ilson

22 Early-Stage Colon Cancer 255
John Krauss, Vaibhav Sahai, and Al B. Benson III

23 Early-Stage Rectal Cancer 267
Hannah J. Roberts, Theodore Hong, and Aparna Parikh

24 Recurrent and Metastatic Colorectal Cancer 283
Joseph Heng and Blase Polite

25 Pancreatic Adenocarcinoma 291
Evan Walker, Andrew Ko, and Margaret Tempero

26 Hepatocellular Cancer 309
Pedro Luiz Serrano Uson Junior and Mitesh Borad

27 Biliary Tract Cancers 319
David B. Zhen and Vaibhav Sahai

28 Carcinoid and Neuroendocrine Tumors 327
Mintallah Haider and Jonathan Strosberg 29 Anal Cancer 343
Asad Mahmood and Rob Glynne-Jones

Part 5 Genitourinary Cancers 359

30 Renal Cancer 361
James L. Coggan, Alan Tan, and Timothy M. Kuzel

31 Bladder Cancer 375
Revathi Kollipara, Alan Tan, and Timothy M. Kuzel

32 Prostate Cancer: Screening, Surveillance, Prognostic Algorithms, and Independent Pathologic Predictive Parameters 389
Eduardo Benzi and Thomas M. Wheeler

33 Early and Locally Advanced Prostate Cancer 399
James Randall, Mohammad R. Siddiqui, Ashley Ross, and Sean Sachdev

34 Metastatic Prostate Cancer 421
Priyanka Chablani, Natalie Reizine, and Walter Stadler

35 Germ Cell Tumors 437
Hamid Emamekhoo, Syed A. Abutalib, and Timothy Gilligan

Part 6 Skin Malignancies 453

36 Melanoma 455
Ana M. Ciurea and Kim Margolin

37 Nonmelanoma Skin Cancers 477
Chrysalyne D. Schmults and Danielle A. Parker

Part 7 Gynecological Cancers 497

38 Ovarian Cancer: Primary Treatment and Approach to Recurrent Disease 499
Rani Bansal, Don Dizon, and Martina Murphy

39 Ovarian Cancer: Second-line Treatment Strategies 511
Maurie Markman

40 Endometrial Cancer 523
Maurie Markman

41 Cancer of the Cervix, Vulva, and Vagina 533
Sabrina M. Bedell and Peter G. Rose

42 Uncommon Gynecologic Cancers 549
Michael Frumovitz, Shannon Westin, and David M. Gershenson

Part 8 Sarcomas 565

43 Bone Sarcomas 567
Nicole Larrier, William Eward, and Richard F. Riedel

44 Soft Tissue Sarcomas 579
Jeffrey Farma, Krisha Howell, and Margaret von Mehren

Part 9 Hereditary Cancer Syndromes and Genetic Testing 595

45 Hereditary Cancer Syndromes 597
Mary B. Daly

46 Hereditary Breast and Ovarian Cancer Syndromes 611
Kristen Whitaker and Elias Obeid

47 Hereditary Gastrointestinal and Pancreatic Cancer Syndromes 625
Kristen M. Shannon, Linda H. Rodgers-Fouche, and Daniel C. Chung

Part 10 Special Issues in Oncology 637

48 Cancer of Unknown Primary 639
Tony Greco

49 Anticoagulation in Cancer 651
Jean Marie Connors

50 Identification and Management of Immunotherapy-Related Adverse Events in Oncology 663
Ozge Gumusay, Laura A. Huppert, Dame Idossa, and Hope S. Rugo

51 Geriatric Oncology 677
Sukeshi Patel Arora and Efrat Dotan

52 Palliative Medicine for Curable and Terminal Cancers 693
Isabelle Blanchard, Kavitha Jennifer Ramachandran, and Divya Gupta

Index 709