The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer

Biology of the NPY family of peptides, their receptors and processing enzymes.- Evolutionary perspective on the NPY-PYY-PP peptides and their receptors.- Function, distribution and molecular pharmacology of NPY-family receptors.- NPY processing in neuronal and non-neuronal tissues by proconvertases.- Dipeptidyl-peptidase IV and aminopeptidase P: molecular switches of NPY/PYY receptor affinities.- The NPY family of peptides in immune disorders and inflammation.- NPY, NPY receptors and DPPIV in innate immunity and autoimmune disorders.- NPY and phagocytic cell functions.- NPY in allergic and respiratory disorders.- NPY analgesia: moving from acute to chronic pain.- The NPY family of peptides and angiogenesis.- NPY as a mediator of neurogenic angiogenesis and revascularization of ischemic tissues.- NPY-induced angiogenesis in retinopathy and wound healing.- NPY in vascular inflammation, remodeling and atherosclerosis.- The NPY family of peptides as growth factors in neurodegenerative diseases and tumor biology.- NPY as a pleiotropic growth factor.- NPY and Hippocampal Neurogenesis.- NPY family of peptides in neural crest-derived tumors.- NPY family of peptides in endocrine, breast and prostate tumors.- Summary.- Future directions and therapeutic perspectives for NPY/PYYbased anti-inflammatory and tumor suppressor drugs.