Oligonucleotides as Therapeutic Agents

A work that includes discussion of the chemistry of oligonucleotide analogues, and reports on structure activity studies and current clinical trials. The book draws on contributions from an interdisciplinary and international group of specialists concerned with research on the subject.

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A work that includes discussion of the chemistry of oligonucleotide analogues, and reports on structure activity studies and current clinical trials, concluding with reviews of applications of ribozymes (RNA enzymes that catalyse RNA cleavage), of aptamers (oligonucleotides which bind specifically to proteins), and discussion of triplex-forming oligonucleotides. The book draws on contributions from an interdisciplinary and international group of specialists concerned with research on all aspects of the use of oligonucleotides as therapeutic agents. Coverage ranges from discussion of the basic chemistry of oligonucleotide synthesis through to the problems of drug delivery and mechanisms of action. It features data from ongoing clinical trials of these highly experimental agents.