Graft vs. Host Disease

James L. Ferrara, Kenneth R. Cooke, H. Joachim Deeg

The Pathophysiology of Graft-vs.-Host Disease. Animal Models of Graft-vs.-Host Disease. Graft-vs.-Host Disease as a Th1-Type Process: Regulation by Th2-Type Cells. Role of T-Cell Costimulation and Regulatory Cells in Allogeneic Hematopoietic Cell Transplantation. Chemokines and Graft-vs.-Host Disease. Graft-vs.-Leukemia Effects. The Immune System in Graft-vs.-Host Disease: Target and Effector Organ. Pathology and Pathogenesis of Cutaneous Graft-vs.-Host Disease. Graft-vs.-Host Disease of the Liver. Intestinal Graft-vs.-Host Disease. The Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation. Clinical Spectrum of Acute Graft-vs.-Host Disease. Role of Minor Histocompatibility Antigens in the Development of Graft-vs.-Host Disease and Graft-vs.-Leukemia Reactivity. Advances in Tissue Typing and Their Potential Impact on GVHD Incidence and Severity. Immunosuppression and Immunophilin Ligands: Cyclosporin, Tacrolimus, and Sirolimus. Prophylaxis and Treatments of Acute Graft-vs.-Host Disease. Graft Manipulation to Prevent Graft-vs.-Host Disease. Graft-vs.-Host Disease in Nonmyeloablative Transplant. Adoptive Immunotherapy in Stem Cell Transplantation. Clinical Spectrum and Therapeutic Approaches to Chronic Graft-vs.-Host Disease. Recent Advances and Future Directions.