Hughes Syndrome

Clinical Aspects.- Hughes Syndrome: History.- Antiphospholipid (Hughes) Syndrome: An Overview.- Epidemiology of Antiphospholipid Syndrome.- Hemocytopenias in Antiphospholipid Syndrome.- Cardiac Manifestations in Antiphospholipid Syndrome.- Cerebral Ischemia in Antiphospholipid Syndrome.- Cerebral Disease Other than Stroke and Transient Ischemic Attack in Antiphospholipid Syndrome.- Skin Manifestations of Antiphospholipid Syndrome.- Kidney Disease in Antiphospholipid Syndrome.- Systemic Hypertension in Antiphospholipid Syndrome.- Pulmonary Hypertension and Antiphospholipid Antibodies.- Osteoarticular Manifestations of Antiphospholipid Syndrome.- The Ear and Antiphospholipid Syndrome.- The Eye in Primary Antiphospholipid Syndrome.- Primary Antiphospholipid Syndrome.- Catastrophic Antiphospholipid Syndrome.- Obstetric Antiphospholipid Syndrome.- Infertility and Antiphospholipid Antibodies.- Transplantation of Solid Organs, Tissues, and Prosthetic Devices in Patients with Antiphospholipid Antibodies.- Antiphospholipid Syndrome in Children.- Ethnic and Geographic Variation in Antiphospholipid Syndrome.- Antiphospholipid Syndrome: Differential Diagnosis.- Laboratory Investigation.- Anticardiolipin Testing.- Lupus Anticoagulants: Mechanistic and Diagnostic Considerations.- ?2-glycoprotein I and Anti-?2-glycoprotein I Antibodies.- Antiprothrombin Antibodies.- Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies.- Basic Aspects.- Vascular Pathology of Antiphospholipid Antibody Syndrome.- Placental Pathology in Antiphospholipid Syndrome.- Antiphospholipid Syndrome — Experimental Models: Insight into Etiology, Pathogenesis, and Treatments.- Antiphospholipid Antibody-Induced Pregnancy Loss and Thrombosis.-Mechanism of Thrombosis in Antiphospholipid Syndrome: Binding to Platelets.- Interaction of Antiphospholipid Antibodies with Endothelial Cells.- The Influence of Antiphospholipid Antibodies on the Protein C Pathway.- Contribution of Tissue Factor to the Pathogenesis of Thrombosis in Patients with Antiphospholipid Syndrome.- Annexins in Antiphospholipid Syndrome.- Plasminogen Activation, Fibrinolysis, and Cell Proteolytic Activity in Antiphospholipid Syndrome.- Lessons from Sequence Analysis of Monoclonal Antiphospholipid Antibodies.- Apoptosis and Antiphospholipid Antibodies.- Accelerated Atherogenesis and Antiphospholipid Antibodies.- Genetics of Antiphospholipid Syndrome.- Infection and Drug-Induced Antiphospholipid Antibodies.- Therapy.- Management of Thrombosis in Antiphospholipid Syndrome.- Management of Antiphospholipid Syndrome in Pregnancy.- Management of Thrombocytopenia in Hughes Syndrome.- The Future of Hughes Syndrome.