Cancer Consult: Expertise in Clinical Practice

Syed Ali Abutalib, MD, is Co-Director of Hematology and Stem Cell Transplantation and Clinical Director of NMDP® Apheresis Center at the Midwest Branch of Cancer Treatment Centers of America, (CTCA), an affiliate of City of Hope.

Maurie Markman, MD, Maurie Markman, MD, is President of Medicine & Science, Cancer Treatment Centers of America, an affiliate of City of Hope.

James O. Armitage, MD, is the Joe Shapiro Professor of Medicine at University of Nebraska Medical Center and has served as Dean for College of Medicine and Chairman of Internal Medicine. He is past President of both the ASCO and the ASTCT

Kenneth Anderson, MD, is the Kraft Family Professor of Medicine at Harvard Medical School, as well as Director of the LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center at Dana-Farber Cancer Institute. He is past President of ASH.

Hope S. Rugo, MD, FASCO, is Director of Breast Oncology and Clinical Trials Education and a Professor of Medicine at the University of California San Francisco Comprehensive Cancer Center.

Al B. Benson III, M.D FACP FASCO is a Professor of Medicine in the Division of Hematology/Oncology at Northwestern University’s Feinberg School of Medicine in Chicago, Illinois, and the Associate Director for Cooperative Groups at the Robert H. Lurie Comprehensive Cancer Center.

Editors Volume 2 xii

Preface xiii

Author Bios xv

Acknowledgement xvii

Volume 1: Solid Tumors & Supportive Care

Volume 1 Editors:
Syed A. Abutalib, Maurie Markman, Al B. Benson III, and Hope S. Rugo

Part 1 Acute Lymphoblastic Leukemia in Adults 1

1 Prognostic Markers and Models in Acute Lymphoblastic Leukemia 3
Dieter Hoelzer

2 Acute Lymphoblastic Leukemia—Treatment and Outcomes in B-ALL 11
Vijaya Raj Bhatt, Prajwal Dhakal, and Syed A. Abutalib

3 T Cell Acute Lymphoblastic Leukemia and Acute Lymphoblastic Lymphoma 27
Syed A. Abutalib and Daniel J. DeAngelo

4 Minimal Residual Disease in Acute Lymphoblastic Leukemia 51
Caner Saygin, Sarah Monick, and Wendy Stock

5 Hematopoietic Transplantation and Cellular Therapy in Acute Lymphoblastic Leukemia 63
Yael Morgenstern, Netanel A. Horowitz, and Jacob M. Rowe

Part 2 Acute Myeloid Leukemia in Adults 81

6 Prognosis in Acute Myeloid Leukemia: Beyond Cytogenetics 83
Caner Saygin and Lucy A. Godley

7 Young Adults with Acute Myeloid Leukemia 93
Sangeetha Venugopal and Farhad Ravandi

8 Older Adults with Acute Myeloid Leukemia 103
Mary-Elizabeth Percival and Elihu Estey

9 Acute Promyelocytic Leukemia 113
Eytan M. Stein and Martin S. Tallman

10 Measurable Residual Disease in Acute Myeloid Leukemia 121
Marie Bill and Hans Beier Ommen

11 Hematopoietic Cell Transplantation and Cellular Therapy in Acute Myeloid Leukemia 133
Piyanuch Kongtim and Stefan O. Ciurea

Part 3 Myelodysplastic Syndromes and Familial Myeloid Neoplasms 147

12 Diagnosis of Myelodysplastic Syndromes 149
Jay Yang, Vijendra Singh, Ali Gabali, and Charles A. Schiffer

13 Treatment of Myelodysplastic Syndromes 165
Rami S. Komrokji

14 Hematopoietic Cell Transplantation and Cellular Therapy in Myelodysplastic Syndromes 179
Ibrahim Yakoub-Agha

15 Familial Myeloid Neoplasms—When to Suspect and What to Do? 191
Ryan J. Stubbins, Amy M. Trottier , Simone Feurstein, and Lucy A. Godley

Part 4 Myeloproliferative Neoplasms 211

16 Chronic Myeloid Leukemia: Chronic Phase Disease 213
Jerald P. Radich

17 Chronic Myeloid Leukemia: Advance Phases of the Disease 221
Michael J. Mauro

18 Chronic Myeloid Leukemia: Treatment Safety During Reproductive Age and Pregnancy 229
Michael J. Mauro

19 Chronic Myeloid Leukemia: Cessation of Therapy 235
Anand A. Patel and Richard A. Larson

20 Hematopoietic Cell Transplantation in Chronic Myeloid Leukemia 243
Jerald P. Radich

21 Polycythemia Vera 255
Prithviraj Bose and Srdan Verstovsek

22 Essential Thrombocythemia 265
Paola Guglielmelli and Alessandro Maria Vannucchi

23 Primary Myelofibrosis 275
Douglas Tremblay, Sangeetha Venugopal, John Mascarenhas, and Ruben Mesa

24 Hematopoietic Cell Transplantation and Cellular Therapy in Primary and Post ET/PV Myelofibrosis 287
Jerry Luo, Irum Khan, and Damiano Rondelli

25 Chronic Myelomonocytic Leukemia 305
Mrinal M. Patnaik

26 Eosinophilic Myeloproliferative Disorders 315
Jason Gotlib

Part 5 Chronic Lymphocytic and Other Leukemias 331

27 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 333
Jayastu Senapati, Nitin Jain, and Susan O'Brien

28 Hematopoietic Cell Transplantation and Cellular Therapy in Chronic Lymphocytic Leukemia 345
Ajay Major, Michael R. Bishop, and Peter A. Riedell

29 Prolymphocytic Leukemia 357
Dima El-Sharkawi and Claire Dearden

30 Hairy Cell Leukemia 371
Justin M. Watts and Martin S. Tallman

Part 6 Hodgkin Lymphoma 385

31 Classic Hodgkin Lymphoma 387
Christopher R. D'Angelo, James O. Armitage, and Nancy L. Bartlett

32 Nodular Lymphocyte-Predominant Hodgkin Lymphoma 401
Dennis A. Eichenauer

33 Hematopoietic Cell Transplantation and Cellular Therapy in Hodgkin Lymphoma 408
Narendranath Epperla, Alex F. Herrera, and Matthew Mei

Part 7 Non-Hodgkin's Lymphomas 417

34 Pitfalls in the Diagnosis of Non-Hodgkin's Lymphomas 419
Carmen Barcena and Laurence de Leval

35 Follicular Lymphoma 435
Danielle Wallace, Nancy Torres, and Carla Casulo

36 Mantle Cell Lymphoma 447
Christina Poh and Stephen D. Smith

37 Marginal Zone Lymphoma 455
Erin Mulvey, Wayne Tam, and Peter Martin

38 Hematopoietic Cell Transplantation and Cellular Therapy in Indolent Non-Hodgkin's Lymphomas 471
Karthik Nath and Craig S. Sauter

39 Diffuse Large B Cell Lymphoma 485
Alessia Castellino and Grzegorz S. Nowakowski

40 Hematopoietic Cell Transplantation and Cellular Therapy in Diffuse Large B Cell Lymphoma 499
Shreya Desai, Syed Maaz Tariq, Arjun Patel, Istvan Redei, and Syed A. Abutalib

41 Primary Mediastinal Large B Cell Lymphoma 515
Alessandro Broccoli and Pier Luigi Zinzani

42 Double-Hit and Double-Expressor Lymphomas 525
David A. Russler-Germain and Brad S. Kahl

43 Transformed Lymphoma 539
Frederique St-Pierre and Jane N. Winter

44 Burkitt Lymphoma 555
Mark Roschewski and Wyndham Wilson

45 Primary and Secondary CNS Lymphomas 563
Leon D. Kaulen, Nicholas A. Blondin, Fred H. Hochberg, and Joachim M. Baehring

46 HIV-Associated Lymphoma 579
Elif Yilmaz and Kieron Dunleavy

47 Waldenström's Macroglobulinemia 589
Morie A. Gertz

48 Primary Cutaneous Lymphomas 599
Nicholas A. Trum, Jasmine Zain, Steven T. Rosen, and Christiane Querfeld

49 Mycosis Fungoides and Sézary Syndrome 635
Robert Stuver, Alison Moskowitz, Sarah Noor, and Steven M. Horwitz

50 Peripheral T-Cell Lymphoma 647
Avyakta Kallam and James O. Armitage

Part 8 Plasma Cell Neoplasms and Related Disorders 659

51 Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma 661
Francesco Maura, Dickran Kazandjian, and Ola Landgren

52 Risk Stratification Including Measurable Residual Disease in Multiple Myeloma 673
Charalampos Charalampous and Shaji Kumar

53 Newly Diagnosed Multiple Myeloma: Transplant Eligible 687
Sagar Lonial

54 Newly Diagnosed Multiple Myeloma: Transplant Ineligible 699
Daniele Derudas and Claudio Cerchione

55 Relapsed/Refractory Multiple Myeloma 713
Neha Korde and Saad Z. Usmani

56 Light-chain (AL) Amyloidosis 727
Vaishali Sanchorawala

57 Bispecific T Cell Engager and Cell Based Immune Therapy in Multiple Myeloma 739
Meera Mohan, Parameswaran Hari, and Saurabh Chhabra

Part 9 Special Issues in Neoplastic Hematology and Cellular Therapy 751

58 Treatment of Lymphomas During Pregnancy 753
Kieron Dunleavy, Emanuele Zucca, and Fedro A. Peccatori

59 Complications and Management of CAR T Cell Therapy 767
Radowan A. Elnair and Matthew A. Lunning

60 Acute Graft-versus-Host Disease 781
Aaron Etra, Uroosa Ibrahim, Jacques Azzi, and John E. Levine

61 Chronic Graft-versus-Host Disease 793
Andrew Trunk and Daniel R. Couriel

Index 809