Cancer Biomarkers in Diagnosis and Therapeutics (eBook)

This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.

Dr. Adeeb Shehzad is currently serving as Assistant Professor in the Department of Biomedical Engineering and Sciences at School of Mechanical and Manufacturing Engineering, National University Sciences and Technology, Islamabad, Pakistan and editorial board member of journal Pancreatic Disorders and Therapy. He completed his MS (2008-2010) and Ph.D (2010-2014) from School of Life Sciences at Kyungpook National University, Daegu, South Korea. He has earlier served as a Research Professor in the School of Life Sciences at Kyungpook National University, Daegu, South Korea (2014-2015) and Visiting Professor at Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman bin Faisal University (IAU), Dammam, Saudi Arabia (2019-2021). His research interest is mainly oriented to the screening and development of plant isolated compounds as anticancer agents, as well as the in-vitro and in-vivo studies of synthetic drugs on modulation of different signaling pathways in cancers. He has been conferred with various scholarships notably, Kyungpook Honor Scholarship and Higher Education Commission awards for MS and PhD studies. He is also serving as a referee for a well-known research journals, including Cancer Research (UK), Molecules and Cells (South Korea), BBA Molecular Cell Research (UK) and MDPI journals. He has more than 10 years of teaching experience in Cancer Biology, Pharmacology and Biotechnology.

He has also published more than 70 research articles in the peer-reviewed international journal and authored or co-authored numerous book chapters. He is a member of many international scientific societies and organizations importantly, Korean Society of Molecular and Cellular Biology, South Korea, honorary member of Drug Regulatory Authority of Pakistan (DRAP) and Pakistan Pharmacist Association, Pakistan.

 

 

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This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.