New Approaches in Cancer Pharmacology: Drug Design and Development

This monograph discusses the development of new drugs for the treatment of cancer, examining exciting prospects for clinical trials, new biological discoveries and advances in molecular biology.

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The development of new drugs for the treatment of cancer is both medically important and scientifically challenging. The monograph looks at some of the most exciting prospects, e.g., future clinilcal trials, new biological discoveries, and advances in molecular biology. This volume will be of interest to laboratory scientists in the academic sector and the pharmaceutical industry, as well as to medical professionals. The particalar topic covered are: - Experimental models to investigate novel anticancer drugs - Principles in the design of DNA-interactive molecules - Discovery of improved platinum analogues - Pharmacological intervention with signal transduction - Discovery, and design of inhibitors of oncogenic tyrosine kinases. Apoptosis and cancer therapy - Engineering antibodies for targeted cancer therapy