Neuropeptides in Respiratory Medicine

PeterJ. Barnes

Part 1 Innervation of the Airways: Neuropeptides and Classic Innervation - Neural Structures in Human Airways; Functional Autonomic Innervation of the Airways - The Cholinergic and Adrenergic Systems; Neuropeptides in the Lower Airways Investigated by Modem Microscopy; Neural Control of the Upper Respiratory Tract; Peptide Biosynthesis and Secretion - Some Recent Developments and Unresolved Issues; Vasoactive Intestinal Polypeptide in the Respiratory Tract; Neuropeptide Y in the Airways; Sensory Nerves and Tachykinins; Pulmonary Endocrine Cells In Vivo and In Vitro; Molecular Characterization of Autonomic and Neuropeptide Receptors; Autonomic Receptors in the Upper and Lower Airways; Tachykinin Receptor Antagonists; Pulmonary Peptidases - General Principles of Peptide Metabolism and Molecular Biology of Angiotensin Converting Enzyme, Neutral Endopeptidase 24.11, and Carboxypeptidase M; Peptidases in the Respiratory Tract - The Localization and Actions of Carboxypeptidase M. Part 2 Physiological Functions of Neuropeptides in the Airways: The Concept of Neurogenic Inflammation in the Respiratory Tract; Modulation of Neurogenic Inflammation by Peptidase; Control of Airway Vascular Beds; Basophil and Mast Cell Activation - Neuropeptides and Nerves; Inositol Triphosphate and Smooth Muscle Function; Neuropeptides and Airway Macromolecule Secretion; ATP as Neurally Released Modulator of Human Airway Ion Transport; Effects of Neuropeptides on Neurotransmission in the Airways. Part 3 Pathophysiological Contribution of Neuropeptides to Disease: Neuropeptides and Asthma; Inflammatory Mechanisms in Cystic Fibrosis Lung Disease; Allergic Rhinitis; Neuropeptides in Small Cell Lung Carcinoma; Neuroregulation of Pulmonary Immunity - The Roles of Substance P and Vasoactive Intestinal Peptide; Sensory Neuropeptides in an Animal Model of Hyperpnoea-induced Bronchoconstriction; Nitric Oxide and Guanylyl Cyclases - Correlation with Neuropeptides; Neuropeptides in Bronchoalveolar Lavage in Allergic Asthma; Morphology of Neurogenic lnflammation in the Airways - Plasma Protein Movement Across the Airway Mucosa and Epithelium.