Deuterium Oxide and Deuteration in Biosciences

Dr. Chang-Hwei Chen is a biophysicist and professor emeritus of Biomedical Sciences at the School of Public Heath, University at Albany. He is currently a member of the Institute of Health and the Environment at the University at Albany.

Section I. Roles of regular and heavy water in biosciences.- Overview: background and applications.- Characteristics of deuterium oxide versus hydrogen oxide.- Section II. Molecular interactions of deuterium versus hydrogen oxide.- Deuterium bonding versus hydrogen bonding.- Hydrophobic interaction in D2O versus H2O.- Section III. Implications of deuterium oxide and deuteration in biological Systems.- Deuterium oxide and deuteration effects on biomolecules.- Effects of D2O and deuteration on biomembranes.- Section IV. Applications of D2O and deuteration to biochemical reactions.- Biochemical effects of deuterium oxide and deuteration.- Physical methods for investigating D2O and deuteration effects.- Section V. Exploration of deuterium oxide and deuteration in health-related research.- Living cells grown in deuterium oxide and deuteration.- Deuterium oxide and deuteration effects on health issues.- Section VI. Applications of deuterium oxide and deuteration to pharmacology.- Deuterium oxide effects on thermostability of vaccines.- Deuterium oxide and deuteration effects on pharmacology.- Index.