Nuclear Oncology

H. William Strauss H. William Strauss is an Emeritus Professor of Radiology at the Weill Cornell Medical Center and Emeritus Attending Physician at the Molecular Imaging and Therapy Service at the Memorial Sloan Kettering Cancer Center (New York, NY, USA). Some of his previous positions include Chief of Nuclear Medicine and Professor of Radiology at Stanford University School of Medicine (Stanford, CA, USA), Chief of Nuclear Medicine at the Massachusetts General Hospital, and Professor of Radiology at Harvard Medical School (Boston, MA, USA). He also served as Vice-President of Diagnostics Drug Discovery at Bristol-Myers Squibb (Princeton, NJ, USA). He is a prolific investigator with over 700 articles published in the peer-reviewed literature. He is a co-author of 70 book chapters and coeditor of eleven books. He has been widely recognized for his work with named lectureships, life memberships and honorary degrees. He is a member of the American Society of Clinical Investigation and a life member of the American Board of Nuclear Medicine, as well as a fellow of both the American College of Nuclear Physicians and the American College of Nuclear Medicine. In recognition of his seminal studies particularly in cardiovascular nuclear medicine, which have greatly advanced nuclear medicine science and have had exceptionally high clinical impact, he has been awarded the two most prestigious prizes in the field of nuclear medicine, the Georg Charles de Hevesy Nuclear Pioneer Award, and the Benedict Cassen Prize. He is a Past President of the Society of Nuclear Medicine, former editor of The Journal of Nuclear Medicine, and has served on the editorial board of that journal, as well as six other juried publications, among which the European Journal of Nuclear Medicine and Molecular Imaging, Journal of Nuclear Cardiology, Quarterly Journal of Nuclear Medicine and Molecular Imaging. Giuliano Mariani Before retiring from academia, between 2001-2014 Giuliano Mariani has served as Full Professor of Nuclear Medicine at the University of Pisa (Pisa, Italy), where he was also Director of the Postgraduate Specialty School in Nuclear Medicine, and Director of the Regional Center of Nuclear Medicine of the University Hospital of Pisa. Before serving at the University of Pisa, between 1994-2001 he has held similar appointments at the University of Genoa Medical School and at the University Hospital of Genoa (Genoa, Italy). His curriculum studiorum includes MD graduation in 1968 at the Catholic University in Rome (Rome, Italy) and graduation at the Specialty schools of the University of Pisa (Pisa, Italy) in Internal Medicine (1972), Nuclear Medicine (1974), Medical Nephrology (1976), and Radiology (1979), all graduations having been obtained maximum cum laude.His academic career also includes an appointment as Visiting Scientist and Expert Consultant at the Metabolism Branch, National Cancer Institute of the National Institutes of Health (Bethesda, Maryland, USA) between 1974-1978, and as Visiting Professor and Lecturer of Radiology at the Harvard Medical School (Boston, Massachusetts, USA) between 1986-1990. In addition, has received several appointments as an Expert Consultant of the International Atomic Energy Agency (IAEA, Vienna, Austria) for carrying out and developing training programs in Nuclear Medicine throughout the world. Giuliano Mariani's interests span over virtually all clinical applications of Nuclear Medicine, including both diagnostic and therapeutic applications, with an emphasis on the development of novel techniques for radionuclide-based diagnosis and therapy of different tumors. He has published over 325 articles in international peer-reviewed journals and has edited or coedited 25 books covering the diagnostic and therapeutic applications of Nuclear Medicine. He is member of the Editorial Board of the most prestigious international journals of Nuclear Medicine and diagnostic imaging in general, among which European Journal of Nuclear Medicine and Molecular Imaging, The Journal of Nuclear Medicine, AJR American Journal of Roentgenology. In recognition of his established role as an "opinion leader" in the national and international arena, Giuliano Mariani has been named as Honorary Member of the Italian Association of Nuclear Medicine and of the European Association of Nuclear Medicine. Duccio Volterrani Duccio Volterrani is currently Full Professor of Nuclear Medicine at the University of Pisa (Pisa, Italy), where he is also Director of the Postgraduate Specialty School in Nuclear Medicine, and Director of the Regional Center of Nuclear Medicine of the University Hospital of Pisa. Before serving at the University of Pisa, between 1993-1998 he has been staff member of the Nuclear Medicine Unit of the University Hospital of Siena (Siena, Italy), while between 1990-1993 he had been the recipient of a Research Fellowship at the CNR Institute of Clinical Physiology in Pisa. His curriculum studiorum at the University of Pisa includes MD graduation in 1987 and degree of Specialist in Nuclear Medicine in 1990. In 2003 he has been Visiting Scientist at the Nuclear Medicine Service at the Memorial Sloan-Kettering Cancer Center in New York (NY, USA). Professor Volterrani's research interests span across several fields of clinical Nuclear Medicine, including radionuclide investigations on renal function (with special focus on arterial hypertension), brain perfusion, metabolism, and receptor status in dementias and in parkinsonian syndromes, nuclear cardiology, diagnostic and therapeutic applications of Nuclear Medicine in endocrinology, and diagnostic and therapeutic applications of Nuclear Medicine in oncology. He is member of the Editorial Board of the Quarterly Journal of Nuclear Medicine and Molecular Imaging and has published over 115 full articles in international peer-reviewed journals. In addition, he has co-edited five books covering the clinical applications of Nuclear Medicine. Steven M. Larson Steven M. Larson, MD, is Hedvig Hricak Chair, Attending Physician and Member, Molecular Imaging and Targeted Therapy Service of the Department of Radiology, Memorial Hospital; Member and Lab Head of the Larson Laboratory of the Molecular Pharmacology program, Memorial Sloan-Kettering Institute; all components of Memorial Sloan-Kettering Cancer Center (MSKCC, New York, NY, USA). Dr. Larson has board Certification in Nuclear Medicine (1972), and Internal Medicine (1973). He is currently Co-Leader of the Imaging and Radiation Sciences Program for the MSKCC Cancer Center Grant.He is Professor of Radiology of Weil-Cornell Medical Center, and a Fellow of the American College of Nuclear Medicine (ACNM)and of the American College of Radiology (ACR). From 1988 to 2013, Dr. Larson was Chief of Nuclear Medicine at MSKCC during a time of unprecedented growth in capability and relevance of Molecular imaging (MI) and Targeted Radiotherapy (TRT), to both clinical practice and oncologic research. In 2013, he transitioned to full time development of radioatracers for molecular imaging in oncology, and TRT. Over the last decade more that 25 MI and TRT radiopharmaceuticals recorded in over 200 patents have originated from the Larson Laboratory, for MI of anti-cancer drugs, Pre-targeted Radioimmunotherapy, and Precision Medicine of common cancers. Dr. Larson has emphasized a team approach to clinical and research developments in nuclear oncology. Clinical interests of his group include the use of positron emission tomography for diagnostic and molecular imaging, and special expertise in the care and management of patients who receive TRT, particularly for thyroid cancer.Advances includedevelopment of novelanalytic paradigms now widely used in radiotracer clinical research, including "Bone Scan Index", Total Lesion Glycolysis, Radiographic Progression for 99mTc-diphosphonatebone scans, "PET-VCAR" and, most recently, "Soothsayer" (a precision biomarker for dosimetry"). His CV includes more than 700 peer reviewed publications. Dr. Larson has received numerous awards from professional organizations for advances in nuclear medicine, including the Cassen Prize, the Hevesy Award, the Henry Wagner Lecture-Medal, the Saul Hertz andAebersold Award, SNMMI/ERF, the Pendergrass award, the Radiology Researcher of the Year (RSNA), and the gold medal (American College of Nuclear Medicine). He is a Member of the National Academy of Medicine of the US National Academy of Sciences. Paola Anna Erba Paola Anna Erba is Associate Professor in Nuclear Medicine at the University of Pisa (Pisa, Italy), and also affiliated with the Department of Nuclear Medicine and Molecular Imaging at the University Medical Center Groningen (Groningen, The Netherlands).She is currently Vice-Director of the Regional Center of Nuclear Medicine of the University Hospital of Pisa, as wellas Vice-Director of the Postgraduate Specialty School in Nuclear Medicine of the University of Pisa (Pisa, Italy), whereshe also holds teaching appointments at the Medical Faculty and for several Courses, Residency Programs and Master courses. Her curriculum studiorum includes MD graduation at the Insubria University (Varese, Italy), the Specialty in Nuclear Medicine at the University of Pisa (Pisa, Italy), followed by Specialty in Clinical Biochemistry at the University of Rome Tor Vergata (Rome, Italy), and Ph.D in "Imaging Cardio-vascular Infection" at the University Medical Center Groningen (Groningen, The Netherlands). Dr. Erba's research interests in Nuclear Medicine span across several fields, including development of new tumor-seeking radiopharmaceuticals in animal models and in human phase-I/II studies, as well as clinical studies on the diagnostic and therapeutic applications of Nuclear Medicine. She has been or still is being Principal Investigator for several projects funded by local and international agencies (including the European Union) focusing on the latest advances based on the "theragnostic" approach using molecular imaging techniques as a tool for personalized medicine in patients with cancers and on the use of artificial intelligence for radiomics analysis. Dr. Erba has co-authored over 200 full articles published in international peer-reviewed journals and has co-edited 5 books covering the clinical applications of Nuclear Medicine. She is also an active member of the European Association of Nuclear Medicine (EANM) where she currently serves as Education Chair of the European School of Multimodality Imaging and Therapy (ESMIT).

Part I Basic Science.- Cancer Biology of Molecular Imaging.- Principles of Molecular Targeting for Radionuclide Therapy.- Single-Photon-Emitting Radiopharmaceuticals for Diagnostic Applications.- Positron-Emitting Radiopharmaceuticals for Diagnostic Applications.- Radiopharmaceuticals for Therapy.- Novel Single-Photon-Emitting Radiopharmaceuticals for Diagnostic Applications.- Novel Positron-Emitting Radiopharmaceuticals.- Novel Radiopharmaceuticals for Therapy.- Physics of Nuclear Oncology.- Instrumentation for Positron Emission Imaging.- Instrumentation for Single-Photon Emission Imaging.- Instrumentation for Intraoperative Detection.- Radiobiology and Radiation Dosimetry in Nuclear Medicine.- Part II Diagnostic Applications of Nuclear Medicine.- Diagnostic Applications of Nuclear Medicine: Lymphomas.- Diagnostic Applications of Nuclear Medicine: Multiple Myeloma.- Diagnostic Applications of Nuclear Medicine: Leukemias.- Diagnostic Applications of Nuclear Medicine: Brain Tumors.-Diagnostic Applications of Nuclear Medicine: Head and Neck Cancer.- Diagnostic Applications of Nuclear Medicine: Thyroid Tumors.- Diagnostic Applications of Nuclear Medicine: Parathyroid Tumors.- Diagnostic Applications of Nuclear Medicine: Breast Cancer.- Diagnostic Applications of Nuclear Medicine: Lung and Mediastinal Tumors.- Diagnostic Applications of Nuclear Medicine: Esophageal Cancers.- Diagnostic Applications of Nuclear Medicine: Gastric Cancers.- Diagnostic Applications of Nuclear Medicine: Gastrointestinal Stromal Tumors.- Diagnostic Applications of Nuclear Medicine: Tumors of the Liver and Biliary Tract.- Diagnostic Applications of Nuclear Medicine: Pancreatic Cancer.- Diagnostic Applications of Nuclear Medicine: Colorectal Cancer.- Diagnostic Applications of Nuclear Medicine: Neuroendocrine Tumors.- Diagnostic Applications of Nuclear Medicine: Kidney and Bladder Cancer.- Diagnostic Applications of Nuclear Medicine: Prostatic Cancer.- Diagnostic Applications of Nuclear Medicine: Testicular Cancer.- Diagnostic Applications of Nuclear Medicine: Penile Cancer.- Diagnostic Applications of Nuclear Medicine: Vulvar Cancer.- Diagnostic Applications of Nuclear Medicine: Uterine Cancers.- Diagnostic Applications of Nuclear Medicine: Ovarian Cancer.- Diagnostic Applications of Nuclear Medicine: Sarcomas.- Diagnostic Applications of Nuclear Medicine: Malignant Melanoma.- Diagnostic Applications of Nuclear Medicine: Pediatric Cancers.- Part III Radionuclide Therapy.- Radionuclide Therapy of Lymphomas.- Radionuclide Therapy of Leukemias and Multiple Myeloma.- Radionuclide Therapy of Thyroid Tumors.- Neuroendocrine Tumors: Therapy with Radiolabeled Peptides.- Neuroendocrine Tumors: Therapy with 131I-MIBG.- Targeted Radionuclide Therapy for Bone Metastasis.- Radionuclide Therapy of Tumors of the Liver and Biliary Tract.- Part IV Radioguided Surgery.- Radioguided Surgery for Breast Cancer.- Radioguided Surgery for Malignant Melanoma.- Radioguided Surgery for Head and Neck Cancer.- Radioguided Surgery: Novel Applications.- Part V Heart Disease in the Cancer Patient.- Imaging the Heart in the Cancer Patient.- Part VI Adverse Effects of Cancer Therapy.- Nuclear Medicine in the Assessment of Adverse Effects of Cancer Therapy in the Lung, Kidney, and Gastrointestinal Tract.- Part VII Teaching Cases in Nuclear Oncology.- Teaching Cases in Nuclear Oncology: Lymphomas.- Teaching Cases in Nuclear Oncology: Multiple Myeloma.- Teaching Cases in Nuclear Oncology: Brain Tumors.- Teaching Cases in Nuclear Oncology: Head and Neck Cancer.- Teaching Cases in Nuclear Oncology: Thyroid Tumors.- Teaching Cases in Nuclear Oncology: Parathyroid Tumors.- Teaching Cases in Nuclear Oncology: Breast Cancer.- Teaching Cases in Nuclear Oncology: Lung and Mediastinal Tumors.- Teaching Cases in Nuclear Oncology: Esophageal Cancers.- Teaching Cases in Nuclear Oncology: Gastric Cancers.- Teaching Cases in Nuclear Oncology: Small Bowel Cancers.- Teaching Cases in Nuclear Oncology: Tumors of the Liver and Biliary Tract.- Teaching Cases in Nuclear Oncology: Pancreatic Cancer.- Teaching Cases in Nuclear Oncology: Colorectal Cancer.- Teaching Cases in Nuclear Oncology: Neuroendocrine Tumors.- Teaching Cases in Nuclear Oncology: Kidney and Bladder Cancer.- Teaching Cases in Nuclear Oncology: Prostatic Cancer.- Teaching Cases in Nuclear Oncology: Testicular Cancer.- Teaching Cases in Nuclear Oncology: Penile Cancer.- Teaching Cases in Nuclear Oncology: Vulvar Cancer.- Teaching Cases in Nuclear Oncology: Uterine Cancers.- Teaching Cases in Nuclear Oncology: Ovarian Cancer.- Teaching Cases in Nuclear Oncology: Sarcomas.- Teaching Cases in Nuclear Oncology: Malignant Melanoma.- Teaching Cases in Nuclear Oncology: Pediatric Cancers.- Teaching Cases in Nuclear Oncology: Investigating the Heart in Cancer Patients.