Precision Molecular Pathology of Glioblastoma

José Javier Otero, M.D., Ph.D. Director of NeuropathologyThe Ohio State University College of MedicineDepartment of Pathology333 West 10th Ave.Columbus, OH 43210
Dr. Otero is the Director of Neuropathology at The Ohio State University College of Medicine. Neuropathology at Ohio State is responsible for all Surgical Neuropathology and Autopsy Diagnostics for James Cancer Center and Wexner Medical Center, in addition to reviewing consults from community pathologists throughout the United States. Dr. Otero obtained his M.D., Ph.D. degree from Northwestern University (Chicago, IL) where he was mentored by Dr. John Kessler during his graduate dissertation. He then transitioned to University of California, San Francisco for anatomic pathology and neuropathology residency, followed by a post-doctoral fellowship in the laboratory of Dr. David Rowitch. Dr. Otero is an expert in developmental neurobiology and surgical neuropathology.

Part I: General Principles.- Epidemiology and etiology of glioblastoma.- The role of Molecular Genetics of Glioblastoma in the Clinical Setting.- Neurosurgical Approach to the Patient with Glioblastoma.- Machine Learning Approaches Pertinent to Glioma Classification.- Histopathology of Adult and Pediatric Glioblastoma.- Principles of Radiation Therapy for Glioblastoma Patients.- 'Implementing Molecular Pathology in a Developing Country.- Part II: Molecular Pathology of Glioblastoma.- Molecular Stratification of Adult and Pediatric High Grade Gliomas.- Genomic Heterogeneity of Aggressive Pediatric and Adult Diffuse Astrocytomas.- Immunohistochemical Surrogates for Molecular Pathology.- Part III:  Key Molecular Pathways in Glioblastoma Development and Progression.- Learning-Based Automated Methods for Brain Tumor Segmentation, Subtype Classification, Tracking and Patient Survival Prediction.- Rodent Brain Tumor Models for Neuro-Oncology Research.- Stem cell based modelling of glioblastoma.- The Neuroscience of Glioblastoma