Study Guide for Goldfrank's Toxicologic Emergencies

McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide Lewis R. Goldfrank, MD, FACEP, FAAEM, FAACT, FACMT, FACP Professor and Chair, Department of Emergency Medicine, New York University School of Medicine; Director, Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Medical Director, New York City Poison Center, New York, New York. McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

Historical Principles and Perspectives







Toxicologic Misfortunes and Catastrophes in History











PART A

THE GENERAL APPROACH TO THE PATIENT





Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes







Principles of Managing the Acutely Poisoned or Overdosed Patient







SC1. Principles of Antidote Stocking







Decontamination Principles: Prevention of Gastrointestinal Absorption









SC2. Decontamination Principles: Prevention of Dermal, ophthalmic and inhalational Absorption



A1. Activated Charcoal



A2. Whole-Bowel Irrigation and Other Intestinal Evacuants





Principles and Techniques Applied to Enhance Elimination









Laboratory Principles







Principles of Diagnostic Imaging







Pharmacokinetic and Toxicokinetic Principles











PART B

THE FUNDAMENTAL PRINCIPLES OF MEDICALTOXICOLOGY





SECTION I

BIOCHEMICAL AND MOLECULAR CONCEPTS





Chemical Principles









Biochemical and Metabolic Principles







Fluid, Electrolyte, and Acid–Base Principles









Neurotransmitters and Neuromodulators









Withdrawal Principles







SECTION II

PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS





Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles







Cardiologic Principles II: Hemodynamics









Dermatologic Principles









SC3. Transdermal Toxicology





Gastrointestinal Principles









Genitourinary Principles









Hema
tologic Principles









Hepatic Principles









Neurologic Principles







Oncologic Principles









Ophthalmic Principles









Otolaryngologic Principles









Psychiatric Principles







SC4. patient violence









Respiratory Principles









Thermoregulatory Principles







SECTION III

SPECIALPOPULATIONS





Reproductive and Perinatal Principles









Pediatric Principles









Geriatric Principles







PART C

THE CLINICAL BASIS OF MEDICAL TOXICOLOGY



SECTION I

A. ANALGESICS ANDANTIINFLAMMATORY MEDICATIONS









Acetaminophen









A3. N-Acetylcysteine





Colchicine, Podophyllin, and the Vinca Alkaloids









Nonsteroidal Antiinflammatory Drugs









Opioids









A4. opioid antagonists



SC5. Internal Concealment of Xenobiotics



SC6. Harm Reduction for Opioid Overdose





Salicylates









A5. sodium bicarbonate





B. Food, Diet, and Nutrition





Botulism







A6. botulinum antitoxin





Food Poisoning







Dieting Xenobiotics and Regimens







Athletic Performance Enhancers







Essential Oils







Plant and Animal-Derived Dietary Supplements







Vitamins







Iron









A7. deferoxamine

Mary Ann Howland



C. pharmaceuticals





Pharmaceutical Additives







Antidiabetics and Hypoglycemics/Antiglycemics









A8. Dextrose(d-Glucose)



A9. octreotide





Antiepileptics









A10. l-carnitine





Antihistamines and Decongestants







A11. physostigmine salicylate









Chemotherapeutics







Methotrexate,5-Flourouracil, and Capecitabine









A12. folates: leucovorin (Folinic acid) and Folic Acid



A13. glucarpidase(carboxypeptidase g2)



A14. uridine triacetate



SC7. Inadvertent Intrathecal Administration of Xenobiotics



SC8. Extravasation of Chemotherapeutics





Antimigraine Medications







Thyroid and Antithyroid Medications









D. Antimicrobials





Antibacterials, Antifungals, and Antivirals







Antimalarials









Antituberculous Medications











A15. pyridoxine



E. Cardiopulmonary Medications



CASE STUDY 4





Antidysrhythmics









A16. Magnesium Sulfate





Antithrombotics









A17. Protein Complex Concentrate and Novel Antithrombotic Antidotes



A18. Vitamin k1



A19. protamine





β-Adrenergic Antagonists







A20. Glucagon