Signal Transducers and Activators of Transcription (STATs)

1. Introduction: a brief history of the STATs and a glance at the future.- Section I Stat Proteins and Their Regulators.- 2. The STAT protein family.- 3. The Janus kinase protein family.- 4. Structural bases of receptor-JAK-STAT interactions.- 5. SOCS proteins: negative regulators of the JAK/STAT pathway.- 6. The PIAS protein family and TC-PTP.- 7. Prime time for the Drosophila JAK/STAT pathway.- 8. The STAT proteins of Dictyostelium.- 9. JAK/STATs in zebrafish: conservation of JAK/STAT signaling in vertebrates.- Section II Mechanisms of Activation of and Transcriptional Regulation by Stat Proteins.- 10. IFNs and STATs, an incestuous relationship.- 11. Mechanisms and biological roles of STAT activation by the IL-6 family of cytokines.- 12. Growth hormone induced activation and regulation of JAK2 and STAT proteins.- 13. G protein-coupled-receptor mediated STAT activation.- 14. Regulation of STATs by posttranslational modifications.- 15. Interactions of STATs with SRC family kinases.- 16. The role of phosphatases and reactive oxygen species in regulation of the JAK/STAT pathway.- 17. Raft-STAT signaling and transcytoplasmic trafficking.- 18. Nuclear trafficking of STAT proteins.- 19. Interaction of STAT signals with other signaling pathways.- 20. Forward genetics in mammalian cells.- 21. X-ray crystal structure of STAT proteins and structure-activity relationships.- 22. STAT transcriptional activation mechanisms: communication with the basal transcriptional machinery.- 23. STAT-dependent gene expression without tyrosine phosphorylation.- Section III Biological Impact of Stat Activation.- 24. JAK/STAT signaling: a tale of jeeps and trains.- 25. Viruses and STAT proteins: co-evolution with the JAK-STAT pathway.- 26. STATs in immune responses to viral infections.- 27. IFN, receptor-STAT1 signaling and cancer immunoediting.- 28. STAT activation in TH1/TH2 differentiation.- 29. Mechanisms and biological consequences of STAT signaling by cytokines that share the common cytokine receptor ? chain, ?C 435.- 30. STAT activation in the acute phase response.- 31. STAT3 function in vivo.- 32. Tissue-specific function of STAT3.- 33. Role of STATs in the biological functions of growth hormone.- 34. STAT/SOCS family members in inflammation and diseases.- 35. Signal Transducers and Activators of Transcription in cytokine signaling.- 36. STAT signaling by erythropoietin.- 37. STATs in cell mobility and polarity during morphogenetic movement.- 38. Negative regulators of STAT function in Drosophila.- 39. Jak3 and the pathogenesis of severe combined immunodeficiency.- 40. Constitutively active STATs and cellular transformation.- 41. STAT proteins as molecular targets for cancer therapy.- 42. STATs in the central nervous system.- 43. STATs in the cardiovascular system.- 44. JAKs and STATs as biomarkers of disease.- 45. Drug discovery approaches targeting the JAK/STAT pathway.- Author Index.